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- Olof Patrik Rorsman
Olof Patrik Rorsman
Professor
Department ofAbout Olof Patrik Rorsman
Professor
Principal Investigator
Research group: Diabetes and pancreatic islets
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Glucose Controls Glucagon Secretion by Regulating Fatty Acid Oxidation in Pancreatic
α-Cells
Sarah L. Armour, Alexander Frueh, Margarita V. Chibalina, Haiqiang Dou, Lidia Argemi-Muntadas, Alexander Hamilton, Georgios Katzilieris-Petras, Peter Carmeliet, Benjamin Davies, Thomas Moritz, Lena Eliasson, Patrik Rorsman, Jakob G. Knudsen
DIABETES - 2023 -
Platelet-derived lipids promote insulin secretion of pancreatic beta
cells
T. Karwen, K. Kolczynska-Matysiak, C. Gross, M. C. Loffler, M. Friedrich, A. Loza-Valdes, W. Schmitz, M. Wit, F. Dziaczkowski, A. Belykh, J. Trujillo-Viera, R. El-Merahbi, C. Deppermann, S. Nawaz, B. Hastoy, A. Demczuk, M. Erk, M. R. Wieckowski, Patrik Rorsman, K. G. Heinze, D. Stegner, B. Nieswandt, G. Sumara
Embo Molecular Medicine - 2023 -
GLP-1 metabolite GLP-1(9-36) is a systemic inhibitor of mouse and human pancreatic islet glucagon
secretion
Nikhil Gandasi, Rui Gao, Lakshmi Kothegala, Abigail Pearce, Cristiano Santos, Samuel Acreman, Davide Basco, Anna Benrick, Margarita V. Chibalina, Anne Clark, Claudia Guida, Matthew Harris, Paul R. V. Johnson, Jakob G. Knudsen, Jinfang Ma, Caroline Miranda, Makoto Shigeto, Andrei I. Tarasov, Ho Yan Yeung, Bernard Thorens, Ingrid Wernstedt Asterholm, Quan Zhang, Reshma Ramracheya, Graham Ladds, Patrik Rorsman
DIABETOLOGIA - 2023 -
Metabolic Messengers:
glucagon
P. E. MacDonald, Patrik Rorsman
Nature Metabolism - 2023 -
Adipocyte-specific ablation of the Ca2+ pump SERCA2 impairs whole-body metabolic function and reveals the diverse metabolic flexibility of white and brown adipose
tissue.
Marco Bauzá-Thorbrügge, Elin Banke, Belén Chanclón, Eduard Peris, Yanling Wu, Musovic Saliha, Cecilia Jönsson, Peter Strålfors, Patrik Rorsman, Charlotta S Olofsson, Ingrid Wernstedt Asterholm
Molecular metabolism - 2022 -
A critical role of the mechanosensor PIEZO1 in glucose-induced insulin secretion in pancreatic
beta-cells
Y. Y. Ye, M. Barghouth, Haiqiang Dou, C. Luan, Y. Z. Wang, A. Karagiannopoulos, X. P. Jiang, U. Krus, M. Fex, Q. Zhang, L. Eliasson, Patrik Rorsman, E. M. Zhang, E. Renstrom
Nature Communications - 2022 -
Hindbrain insulin controls feeding
behavior
Kim Eerola, Francesco Longo, Thomas Reinbothe, Jennifer E. Richard, Olesya Shevchouk, Lorena Lopez-Ferreras, Devesh Mishra, Mohammed Asker, Johan Tolö, Caroline Miranda, Musovic Saliha, Charlotta S Olofsson, Patrik Rorsman, Karolina P Skibicka
Molecular Metabolism - 2022 -
Every islet matters: improving the impact of human islet
research
A. L. Gloyn, M. Ibberson, P. Marchetti, A. C. Powers, Patrik Rorsman, M. Sander, M. Solimena
Nature Metabolism - 2022 -
Arginine-vasopressin mediates counter-regulatory glucagon release and is diminished in type 1
diabetes.
Angela Kim, Jakob G Knudsen, Joseph C Madara, Anna Benrick, Thomas G Hill, Lina Abdul Kadir, Joely A Kellard, Lisa J. Mellander, Caroline Miranda, Haopeng Lin, Timothy James, Kinga Suba, Aliya F Spigelman, Yanling Wu, Patrick E MacDonald, Ingrid Wernstedt Asterholm, Tore Magnussen, Mikkel Christensen, Tina Vilsbøll, Victoria Salem, Filip K Knop, Patrik Rorsman, Bradford B Lowell, Linford Jb Briant
eLife - 2021 -
The vascular architecture of the pancreatic islets: A homage to August
Krogh
Massimo Muratore, Cristiano Santos, Patrik Rorsman
Comparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology - 2021 -
Nanoscale Amperometry Reveals that Only a Fraction of Vesicular Serotonin Content is Released During Exocytosis from Beta
Cells
Amir Hatamie, Lin Ren, Haiqiang Dou, Nikhil Gandasi, Patrik Rorsman, Andrew G Ewing
Angewandte Chemie-International Edition - 2021 -
'Resistance is futile?' - paradoxical inhibitory effects of K-ATP channel closure in glucagon-secreting
alpha-cells
Q. Zhang, Haiqiang Dou, Patrik Rorsman
Journal of Physiology - 2020 -
Gs/Gq signaling switch in beta cells defines incretin effectiveness in
diabetes
O. S. Oduori, N. Murao, K. Shimomura, H. Takahashi, Q. Zhang, Haiqiang Dou, S. Sakai, K. Minami, Belén Chanclón, C. Guida, Lakshmi Kothegala, Johan Tolö, Y. Maejima, N. Yokoi, Y. Minami, T. Miki, Patrik Rorsman, S. Seino
Journal of Clinical Investigation - 2020 -
Peripancreatic adipose tissue protects against high-fat-diet-induced hepatic steatosis and insulin resistance in
mice
Belén Chanclón, Yanling Wu, Milica Vujičić, Marco Bauzá-Thorbrügge, Elin Banke, Peter Micallef, Julia Kanerva, Björn Wilder, Patrik Rorsman, Ingrid Wernstedt Asterholm
International Journal of Obesity - 2020 -
Incretin hormones, insulin, glucagon and advanced glycation end products in relation to cognitive function in older people with and without diabetes, a population-based
study
E. Dybjer, G. Engstrom, C. Helmer, K. Nagga, Patrik Rorsman, P. M. Nilsson
Diabetic Medicine - 2020 -
Somatostatin secretion by Na+-dependent Ca2+-induced Ca2+ release in pancreatic
delta-cells.
Elisa Vergari, Geoffrey Denwood, Albert Salehi, Quan Zhang, Julie Adam, Ahmed Alrifaiy, Ingrid Wernstedt Asterholm, Anna Benrick, Margarita V Chibalina, Lena Eliasson, Claudia Guida, Thomas G Hill, Alexander Hamilton, Reshma Ramracheya, Frank Reimann, Nils J G Rorsman, Ioannis Spilliotis, Andrei I Tarasov, Jonathan N Walker, Patrik Rorsman, Linford J B Briant
Nature metabolism - 2020 -
A method for the generation of human stem cell-derived alpha
cells
Q. P. Peterson, A. Veres, L. H. Chen, M. Q. Slama, J. H. R. Kenty, S. Hassoun, M. R. Brown, Haiqiang Dou, C. D. Duffy, Q. Zhou, A. V. Matveyenko, Björn Tyrberg, M. Sorhede-Winzell, Patrik Rorsman, D. A. Melton
Nature Communications - 2020 -
"Take Me To Your Leader": An Electrophysiological Appraisal of the Role of Hub Cells in Pancreatic
Islets
L. S. Satin, Q. Zhang, Patrik Rorsman
Diabetes - 2020 -
Glucose stimulates somatostatin secretion in pancreatic delta-cells by cAMP-dependent intracellular Ca-2+
release
G. Denwood, A. Tarasov, Albert Salehi, L. Vergari, R. Ramracheya, H. Takahashi, V. O. Nikolaev, S. Seino, F. Gribble, F. Reimann, Patrik Rorsman, Q. Zhang
Journal of General Physiology - 2019 -
Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic
beta-cells
E. Haythorne, M. Rohm, M. van de Bunt, M. F. Brereton, A. I. Tarasov, T. S. Blacker, G. SachseqF, M. S. dos Santos, R. T. Exposito, S. Davis, O. Baba, R. Fischer, M. R. Duchen, Patrik Rorsman, J. I. MacRae, Frances M. Ashcroft
Nature Communications - 2019 -
Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin
secretion
E. Vergari, J. G. Knudsen, R. Ramracheya, Albert Salehi, Q. Zhang, J. Adam, Ingrid Wernstedt Asterholm, Anna Benrick, L. J. B. Briant, M. V. Chibalina, F. M. Gribble, A. Hamilton, B. Hastoy, F. Reimann, N. J. G. Rorsman, II Spiliotis,, A. Tarasov, Yanling Wu, Frances M. Ashcroft, Patrik Rorsman
Nature Communications - 2019 -
Dysregulation of Glucagon Secretion by Hyperglycemia-Induced Sodium-Dependent Reduction of ATP
Production
J. G. Knudsen, A. Hamilton, R. Ramracheya, A. I. Tarasov, M. Brereton, E. Haythorne, M. V. Chibalina, P. Spegel, H. Mulder, Q. Zhang, F. M. Ashcroft, J. Adam, Patrik Rorsman
Cell Metabolism - 2019 -
The somatostatin-secreting pancreatic delta-cell in health and
disease
Patrik Rorsman, M. O. Huising
Nature Reviews Endocrinology - 2018 -
Monitoring real-time hormone release kinetics: Via high-content 3-D imaging of compensatory
endocytosis
A. I. Tarasov, J. Galvanovskis, O. Rorsman, A. Hamilton, E. Vergari, P. R. V. Johnson, F. Reimann, Frances M. Ashcroft, Patrik Rorsman
Lab on a Chip - 2018 -
Electrophysiological properties of human beta-cell lines EndoC-beta H1 and -beta H2 conform with human
beta-cells
B. Hastoy, M. Godazgar, A. Clark, V. Nylander, I. Spiliotis, M. van de Bunt, M. V. Chibalina, A. Barrett, C. Burrows, A. I. Tarasov, R. Scharfmann, A. L. Gloyn, Patrik Rorsman
Scientific Reports - 2018 -
GLP-1 suppresses glucagon secretion in human pancreatic alpha-cells by inhibition of P/Q-type Ca2+
channels
R. Ramracheya, C. Chapman, M. Chibalina, Haiqiang Dou, Caroline Miranda, A. Gonzalez, Y. Moritoh, M. Shigeto, Q. Zhang, M. Braun, A. Clark, P. R. Johnson, Patrik Rorsman, L. J. B. Briant
Physiological Reports - 2018 -
Adrenaline stimulates glucagon secretion by Tpc2-Dependent ca2+ mobilization from acidic stores in pancreatic
a-Cells
A. Hamilton, Q. Zhang, Albert Salehi, M. Willems, J. G. Knudsen, A. K. Ringgaard, C. E. Chapman, A. Gonzalez-Alvarez, N. C. Surdo, M. Zaccolo, D. Basco, P. R. V. Johnson, R. Ramracheya, G. A. Rutter, A. Galione, Patrik Rorsman, A. I. Tarasov
Diabetes - 2018 -
CPT1a-Dependent Long-Chain Fatty Acid Oxidation Contributes to Maintaining Glucagon Secretion from Pancreatic
Islets
L. J. B. Briant, M. S. Dodd, M. V. Chibalina, N. J. G. Rorsman, P. R. V. Johnson, P. Carmeliet, Patrik Rorsman, J. G. Knudsen
Cell Reports - 2018 -
Fusion pore in exocytosis: More than an exit gate? A beta-cell
perspective
B. Hastoy, A. Clark, Patrik Rorsman, J. C. Lang
Cell Calcium - 2017 -
Fumarate Hydratase Deletion in Pancreatic beta Cells Leads to Progressive
Diabetes
J. Adam, R. Ramracheya, M. V. Chibalina, N. Ternette, A. Hamilton, A. I. Tarasov, Q. Zhang, E. Rebelato, N. J. G. Rorsman, R. Martin-del-Rio, A. Lewis, G. Ozkan, H. W. Do, P. Spegel, K. Saitoh, K. Kato, K. Igarashi, B. M. Kessler, C. W. Pugh, J. Tamarit-Rodriguez, H. Mulder, A. Clark, N. Frizzell, T. Soga, Frances M. Ashcroft, A. Silver, Patrick Pollard, Patrik Rorsman
Cell Reports - 2017 -
Anti-diabetic action of all- trans retinoic acid and the orphan G protein coupled receptor GPRC5C in pancreatic
beta-cells
S. Amisten, I. M. Al-Amily, A. Soni, R. Hawkes, P. Atanes, S. J. Persaud, Patrik Rorsman, Albert Salehi
Endocrine Journal - 2017 -
Glucagon secretion from pancreatic
alpha-cells
L. Briant, Albert Salehi, E. Vergari, Q. Zhang, Patrik Rorsman
Upsala Journal of Medical Sciences - 2016 -
PYY-Dependent Restoration of Impaired Insulin and Glucagon Secretion in Type 2 Diabetes following Roux-En-Y Gastric Bypass
Surgery
R. D. Ramracheya, L. J. McCulloch, A. Clark, D. Wiggins, H. Johannessen, M. K. Olsen, X. Cai, C. M. Zhao, D. Chen, Patrik Rorsman
Cell Reports - 2016 -
Dramatis Personae in β-Cell Mass Regulation: Enter
SerpinB1
A. I. Tarasov, Patrik Rorsman
Cell Metabolism - 2016 -
GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5
activation
Makoto Shigeto, R. Ramracheya, A. I. Tarasov, Chae Young Cha, M. V. Chibalina, B. Hastoy, K. Philippaert, Thomas Reinbothe, N. Rorsman, Albert Salehi, W. R. Sones, E. Vergari, C. Weston, J. Gorelik, M. Katsura, V. O. Nikolaev, R. Vennekens, M. Zaccolo, A. Galione, P. R. V. Johnson, K. Kaku, G. Ladds, Patrik Rorsman
Journal of Clinical Investigation - 2015 -
Na+ current properties in islet alpha- and beta-cells reflect cell-specific Scn3a and Scn9a
expression
Q. Zhang, M. V. Chibalina, M. Bengtsson, L. N. Groschner, R. Ramracheya, N. J. G. Rorsman, V. Leiss, M. A. Nassar, A. Welling, F. M. Gribble, F. Reimann, F. Hofmann, J. N. Wood, Frances M. Ashcroft, Patrik Rorsman
Journal of Physiology-London - 2014 -
Overexpression of alpha2A-adrenergic receptors contributes to type 2
diabetes
A. H. Rosengren, R. Jokubka, D. Tojjar, C. Granhall, O. Hansson, D. Q. Li, V. Nagaraj, Thomas Reinbothe, J. Tuncel, L. Eliasson, L. Groop, Patrik Rorsman, Albert Salehi, V. Lyssenko, H. Luthman, E. Renström
Science - 2010 -
Suppression of sulfonylurea- and glucose-induced insulin secretion in vitro and in vivo in mice lacking the chloride transport protein
ClC-3.
Dai-Qing Li, Xingjun Jing, Albert Salehi, Stephan C Collins, Michael B Hoppa, Anders H. Rosengren, Enming Zhang, Ingmar Lundquist, Charlotta S Olofsson, Matthias Mörgelin, Lena Eliasson, Patrik Rorsman, Erik Renström
Cell metabolism - 2009 -
Impaired insulin exocytosis in neural cell adhesion molecule-/- mice due to defective reorganization of the submembrane F-actin
network.
Charlotta S Olofsson, Joakim Håkansson, Albert Salehi, Martin Bengtsson, Juris Galvanovskis, Chris Partridge, Maria SörhedeWinzell, Xiaojie Xian, Lena Eliasson, Ingmar Lundquist, Henrik Semb, Patrik Rorsman
Endocrinology - 2009 -
Deletion of the G protein-coupled receptor 30 impairs glucose tolerance, reduces bone growth, increases blood pressure, and eliminates estradiol-stimulated insulin release in female
mice.
Ulrika E A Mårtensson, S Albert Salehi, Sara H Windahl, Maria F Gomez, Karl Swärd, Joanna Daszkiewicz-Nilsson, Anna Wendt, Niklas Andersson, Per Hellstrand, Per-Olof Grände, Christer Owman, Clifford J Rosen, Martin L Adamo, Ingmar Lundquist, Patrik Rorsman, Bengt-Olof Nilsson, Claes Ohlsson, Björn Olde, L M Fredrik Leeb-Lundberg
Endocrinology - 2009 -
Quantification of mRNA in single cells and modelling of RT-qPCR induced
noise
Martin Bengtsson, Martin Hemberg, Patrik Rorsman, Anders Ståhlberg
BMC Molecular Biology - 2008