Professor, Principal Investigator, MD, PhD, FRCP
Ulf Smith is Professor of Internal Medicine and Director of the Lundberg Laboratory for Diabetes Research at the Sahlgrenska Academy, University of Gothenburg, Sweden. He has held many administrative positions including Chair of the Institute of Medicine, Chief-of-Medicine and Executive Medical Director of the Sahlgrenska University Hospital. He has been member of the Scientific Board of the Sahlgrenska Academy and Dean of Research of the Academy.
Professor Smith is a diabetologist and his research is focused on the pathogenesis of Type 2 diabetes and its complications. He has published around 500 scientific papers in the field and received many honors for his work including being a Fogarty Scholar at the NIH, Bethesda, USA.
Professor Smith is Past President of the European Association for the Study of Diabetes and Chair of the European Foundation for the Study of Diabetes. He is also Past President of the Alliance for Biomedical Research in Europe. He is chairman/member of several Scientific Advisory Boards. He has currently a position as member of the European Commission Scientific Panel for Health at the European Commission.
For information of group members and their work, please visit the website for the Lundberg Laboratory for Diabetes Research.
Main research
For information of group members and their work, please visit the website for the Lundberg Laboratory for Diabetes Research.
Group members
For information of group members and their work, please visit the website for the Lundberg Laboratory for Diabetes Research. Group members
Key Publications
Grünberg JR, Hoffmann JM, Hedjazifar S, Nerstedt A, Jenndahl L, Elvin J, Castellot J, Wei L, Movérare-Skrtic S, Ohlsson C, Mannerås Holm L, Bäckhed F, Syed I, Bosch F, Saghatelian A, Kahn BB, Hammarstedt A and Smith U.
Overexpressing the novel autocrine/endocrine adipokine WISP2 induces hyperplasia of the heart, white and brown adipose tissues and prevents insulin resistance.
Sci Rep. DOI: 10.1038/srep43515, (2017)
Lee S, Zhang C, Kilicarslan M, Piening BD, Bjornson E, Hallström BM, Groen AK, Ferrannini E, Laakso M, Snyder M, Blüher M, Uhlen M, Nielsen J, Smith U, Serlie M, Borén J and Mardinoglu A.
Integrated network analysis reveals an association between plasma mannose levels and insulin resistance.
Cell Metab. 24:172-184. (2016)
Smith U.
Abdominal obesity – a marker of ectopic fat accumulation.
J Clin Invest. 125(5):1790-1792. (2015)
Gustafson B, Hammarstedt A, Hedjazifar S, Hoffman JM, Svensson P-A, Grimsby J, Rondinone C and Smith U.
BMP4 and BMP antagonists regulate human white and beige adipogenesis.
Diabetes. 64:1670-1681. (2015)
Yore MM, Syed IS, Moraes-Vieira PM, Zhang T, Herman MA, Homan E.A, Patel R.T, Lee J, Chen S, Peroni O.D, Dhaneshwar AS, Hammarstedt A, Smith U, McGraw TE, Saghatelian A and Kahn BB.
Discovery of a Class of Endogenous Mammalian Lipids with Anti-Diabetic and Anti-inflammatory Effects.
Cell. 159(2):318-332. (2014)
Hammarstedt A, Hedjazifar S, Jenndahl L, Gogg S, Grünberg J, Gustafson B, Klimcakova E, Stich V, Langin D, Laakso M and Smith U.
WISP2 Regulates Preadipocyte Commitment and PPAR gamma Activation by BMP4.
Proc Natl Acad Sci USA. 110:2563-2568. (2013)
Isakson P, Hammarstedt A, Gustafson B and Smith U.
Impaired preadipocytes differentiation in human abdominal obesity – role of Wnt, TNFalpha and inflammation.
Diabetes. 58:1550-1557. (2009)
Eliasson B, Taskinen M-R and Smith U.
Long-term use of nicotine gum is associated with hyperinsulinemia and insulin resistance.
Circulation. 94:878-881. (1996)
Graham TE, Yang Q, Bluher M, Hammarstedt A, Ciaraldi TP, Henry RR, Wason CJ, Oberbach A, Jansson P-A, Smith U and Kahn BB.
Retinol binding protein 4 and insulin resistance in lean, obese, and diabetic subjects.
N Engl J Med. 354:2552-2563. (2006)
Rondinone CM, Wang L-M, Lönnroth P, Wesslau C, Pierce JH and Smith U.
Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin-dependent diabetes mellitus.
Proc Natl Acad Sci USA. 94:4171-4175. (1997)
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