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Ulf Smith


Ulf Smith
+46 31-342 1104

Postal Address: Su sahlgrenska, 41345 Göteborg
Visiting Address: Blå stråket 5 b wallenberglab/su , 41346 Göteborg

Department of Molecular and Clinical Medicine at Institute of Medicine (More Information)
SU Sahlgrenska
413 45 Göteborg
Fax: +46 31823762
Visiting Address: Blå stråket 5 B Wallenberglab/SU , 413 45 Göteborg

About Ulf Smith

Professor, Principal Investigator, MD, PhD, FRCP

Ulf Smith is Professor of Internal Medicine and Director of the Lundberg Laboratory for Diabetes Research at the Sahlgrenska Academy, University of Gothenburg, Sweden. He has held many administrative positions including Chair of the Institute of Medicine, Chief-of-Medicine and Executive Medical Director of the Sahlgrenska University Hospital. He has been member of the Scientific Board of the Sahlgrenska Academy and Dean of Research of the Academy.

Professor Smith is a diabetologist and his research is focused on the pathogenesis of Type 2 diabetes and its complications. He has published around 500 scientific papers in the field and received many honors for his work including being a Fogarty Scholar at the NIH, Bethesda, USA.

Professor Smith is Past President of the European Association for the Study of Diabetes and Chair of the European Foundation for the Study of Diabetes. He is also Past President of the Alliance for Biomedical Research in Europe. He is chairman/member of several Scientific Advisory Boards. He has currently a position as member of the European Commission Scientific Panel for Health at the European Commission.

For information of group members and their work, please visit the website for the Lundberg Laboratory for Diabetes Research.

Main research

For information of group members and their work, please visit the website for the Lundberg Laboratory for Diabetes Research.

Group members

For information of group members and their work, please visit the website for the Lundberg Laboratory for Diabetes Research. Group members

Key Publications

Grünberg JR, Hoffmann JM, Hedjazifar S, Nerstedt A, Jenndahl L, Elvin J, Castellot J, Wei L, Movérare-Skrtic S, Ohlsson C, Mannerås Holm L, Bäckhed F, Syed I, Bosch F, Saghatelian A, Kahn BB, Hammarstedt A and Smith U.
Overexpressing the novel autocrine/endocrine adipokine WISP2 induces hyperplasia of the heart, white and brown adipose tissues and prevents insulin resistance.
Sci Rep. DOI: 10.1038/srep43515, (2017)

Lee S, Zhang C, Kilicarslan M, Piening BD, Bjornson E, Hallström BM, Groen AK, Ferrannini E, Laakso M, Snyder M, Blüher M, Uhlen M, Nielsen J, Smith U, Serlie M, Borén J and Mardinoglu A.
Integrated network analysis reveals an association between plasma mannose levels and insulin resistance.
Cell Metab. 24:172-184. (2016)

Smith U.
Abdominal obesity – a marker of ectopic fat accumulation.
J Clin Invest. 125(5):1790-1792. (2015)

Gustafson B, Hammarstedt A, Hedjazifar S, Hoffman JM, Svensson P-A, Grimsby J, Rondinone C and Smith U.
BMP4 and BMP antagonists regulate human white and beige adipogenesis.
64:1670-1681. (2015)

Yore MM, Syed IS, Moraes-Vieira PM, Zhang T, Herman MA, Homan E.A, Patel R.T, Lee J, Chen S, Peroni O.D, Dhaneshwar AS, Hammarstedt A, Smith U, McGraw TE, Saghatelian A and Kahn BB.
Discovery of a Class of Endogenous Mammalian Lipids with Anti-Diabetic and Anti-inflammatory Effects.
Cell. 159(2):318-332. (2014)

Hammarstedt A, Hedjazifar S, Jenndahl L, Gogg S, Grünberg J, Gustafson B, Klimcakova E, Stich V, Langin D, Laakso M and Smith U.
WISP2 Regulates Preadipocyte Commitment and PPAR gamma Activation by BMP4.
Proc Natl Acad Sci USA. 110:2563-2568. (2013)

Isakson P, Hammarstedt A, Gustafson B and Smith U.
Impaired preadipocytes differentiation in human abdominal obesity – role of Wnt, TNFalpha and inflammation.
Diabetes. 58:1550-1557. (2009)

Eliasson B, Taskinen M-R and Smith U.
Long-term use of nicotine gum is associated with hyperinsulinemia and insulin resistance.
Circulation. 94:878-881. (1996)

Graham TE, Yang Q, Bluher M, Hammarstedt A, Ciaraldi TP, Henry RR, Wason CJ, Oberbach A, Jansson P-A, Smith U and Kahn BB.
Retinol binding protein 4 and insulin resistance in lean, obese, and diabetic subjects.
N Engl J Med. 354:2552-2563. (2006)

Rondinone CM, Wang L-M, Lönnroth P, Wesslau C, Pierce JH and Smith U.
Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin-dependent diabetes mellitus.
Proc Natl Acad Sci USA. 94:4171-4175. (1997)

Latest publications

Microbiota-Related Metabolites and the Risk of Type 2 Diabetes
J. Vangipurapu, L. F. Silva, T. Kuulasmaa, Ulf Smith, M. Laakso
Diabetes care, Journal article 2020
Journal article

The European medical information framework: A novel ecosystem for sharing healthcare data across Europe
S. Lovestone, B. Vannieuwenhuyse, P. J. Visser, I. Bos, S. Vos et al.
Learning Health Systems, Journal article 2019
Journal article

Epigenetic modifications of the Zfp/ZNF423 gene control murine adipogenic commitment and are dysregulated in human hypertrophic obesity.
Michele Longo, Gregory A Raciti, Federica Zatterale, Luca Parrillo, Antonella Desiderio et al.
Diabetologia, Journal article 2018
Journal article

Methodological Issues in Studying PAHSA Biology: Masking PAHSA Effects.
Ismail Syed, Jennifer Lee, Odile D Peroni, Mark M Yore, Pedro M Moraes-Vieira et al.
Cell metabolism, Journal article 2018
Journal article

Showing 51 - 60 of 165


Increased expression of STK25 leads to impaired glucose utilization and insulin sensitivity in mice challenged with a high-fat diet.
Emmelie Cansby, Manoj Amrutkar, Louise Mannerås Holm, Annika Nerstedt, Azadeh Reyahi et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Journal article 2013
Journal article

WISP2 Regulates Preadipocyte Commitment and PPARgamma Activation by BMP4
Ann Hammarstedt, Shahram Hedjazifar, Lachmi E Jenndahl, Silvia Gogg, John Grünberg et al.
Proceedings of the National Academy of Science of the United States of America, Journal article 2013
Journal article

Mendelian randomization studies do not support a causal role for reduced circulating adiponectin levels in insulin resistance and type 2 diabetes.
Hanieh Yaghootkar, Claudia Lamina, Robert A Scott, Zari Dastani, Marie-France Hivert et al.
Diabetes, Journal article 2013
Journal article

A standardized vascular disease health check in Europe: a cost-effectiveness analysis
C.A Schuetz, P Alperin, S Guda, A van Herick, B Cariou et al.
PLoS ONE, Journal article 2013
Journal article

Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes
Weijia Xie, Andrew Wood, Valeriya Lyssenko, Michael Weedon, Joshua Knowles et al.
Diabetes, Journal article 2013
Journal article

Non-Cholesterol Sterol Levels Predict Hyperglycemia and Conversion to Type 2 Diabetes in Finnish Men
H. Cederberg, H. Gylling, T. A. Miettinen, J. Paananen, J. Vangipurapu et al.
Plos One, Journal article 2013
Journal article


Showing 51 - 60 of 165

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