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A phototherapeutic fluorescent β-cyclodextrin branched polymer delivering nitric oxide.

Journal article
Authors Milo Malanga
Mimimorena Seggio
Vladimir Kirejev
Aurore Fraix
Ivana Di Bari
Eva Fenyvesi
Marica B Ericson
Salvatore Sortino
Published in Biomaterials science
Volume 7
Issue 6
Pages 2272-2276
ISSN 2047-4849
Publication year 2019
Published at Department of Chemistry and Molecular Biology
Pages 2272-2276
Language en
Subject categories Biophysical chemistry, Materials Chemistry, Nano Technology, Biophysics


We report herein on a novel water-soluble β-cyclodextrin-branched polymer covalently integrating a fluorescein moiety and a nitric oxide (NO) photodonor within its macromolecular skeleton. Photoexcitation with visible light induces the parallel activation of the two chromophores, which results in the green fluorescence emission suitable for imaging accompanied by NO release for therapy. In fact, this polymer internalizes in squamous carcinoma cancer cells in vitro, visualized by fluorescence microscopy, and induces cell mortality as result of the NO photo-decaging. The non-covalent drug delivery capability of this new material is also demonstrated using a hydrophobic photosensitizer for photodynamic therapy as a probe.

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Utskriftsdatum: 2020-08-15