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Protein markers predict body composition during growth hormone (GH) treatment in short prepubertal children.

Journal article
Authors Ralph Decker
Björn Andersson
Andreas F M Nierop
Ingvar Bosaeus
Jovanna Dahlgren
Kerstin Albertsson-Wikland
Gunnel Hellgren
Published in Clinical Endocrinology
Volume 79
Issue 5
Pages 675-82
ISSN 0300-0664
Publication year 2013
Published at Institute of Clinical Sciences, Department of Pediatrics
Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
Pages 675-82
Language en
Keywords Proteomics
Subject categories Clinical physiology, Endocrinology


OBJECTIVE: A high-throughput pharmaco-proteomic approach has previously been successfully used to identify lipoprotein biomarkers related to changes in longitudinal growth and bone mass in response to growth hormone (GH) treatment. The aim of this study was to identify protein markers involved in the diverse anabolic and lipolytic remodelling of body composition during GH treatment. DESIGN, PATIENTS AND MEASUREMENTS: The study population consisted of 128 prepubertal children receiving GH treatment. Thirty-nine were short as a result of GH deficiency and 89 had idiopathic short stature (ISS). Serum protein expression profiles at study start and after one year of GH treatment were analysed using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS). Body composition was analysed by dual-energy X-ray absorptiometry (DXA), reliably estimating muscle mass from appendicular (arms and legs) lean soft tissue mass (LST). DXA was also used to estimate appendicular bone mineral content (BMC) and fat mass for the total body. RESULTS: Specific protein expression patterns associated with GH response in different body compartments were identified. Among identified proteins different isoforms of nutrition markers such as apolipoproteins (Apo) were recognized; Apo C-I, Apo A-II, serum amyloid A4 (SAA4) and transthyretin (TTR). In addition, unidentified peaks were associated with GH effects on specific body compartments. CONCLUSIONS: Our results suggest that unique protein markers are associated with remodelling of different body compartments during GH treatment, which in the future might be useful to optimize GH treatment not only with regard to longitudinal growth. © 2013 Blackwell Publishing Ltd.

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