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Aneuploidy in neuroblastoma tumors is not associated with inactivating point mutations in the STAG2 gene.

Journal article
Authors Anna Djos
Susanne Fransson
Per Kogner
Tommy Martinsson
Published in BMC medical genetics
Volume 14
Issue 1
Pages 102
ISSN 1471-2350
Publication year 2013
Published at Institute of Biomedicine, Department of Medical and Clinical Genetics
Pages 102
Language en
Keywords Neuroblastoma, STAG2, Aneuploidy, Numerical aberrations, Chromosomal instability
Subject categories Medical Genetics


Chromosomal instability is a hallmark of human cancer caused by errors in mitotic control and chromosome segregation. STAG2 encodes a subunit of the cohesion complex that participates in mitotic chromatid separation and was recently found to show low expression and inactivating mutations in Ewing's sarcoma, melanoma and glioblastoma.In the childhood tumor neuroblastoma (NB) segmental chromosomal alterations are associated with poor prognosis whereas tumors displaying whole chromosome gains and losses have a much better prognosis.

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