To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

Glia in the pathogenesis … - University of Gothenburg, Sweden Till startsida
Sitemap
To content Read more about how we use cookies on gu.se

Contact form








 


Note! If you want an answer on a question you must specify your email address




Glia in the pathogenesis of neurodegenerative diseases

Journal article
Authors A. Verkhratsky
V. Parpura
Marcela Pekna
Milos Pekny
M. Sofroniew
Published in Biochemical Society Transactions
Volume 42
Pages 1291-1301
ISSN 0300-5127
Publication year 2014
Published at Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
Pages 1291-1301
Language en
Links dx.doi.org/10.1042/bst20140107
Keywords Alzheimer's disease, amyotrophic lateral sclerosis, glia, Huntington's disease, neurodegeneration, AMYOTROPHIC-LATERAL-SCLEROSIS, NEURONAL CEROID-LIPOFUSCINOSIS, FIBRILLARY ACIDIC PROTEIN, SPINAL-CORD-INJURY, BLOOD-BRAIN-BARRIER, TRANSGENIC ANIMAL-MODEL, CELL-CELL INTERACTIONS, HUNTINGTONS-DISEASE, ALZHEIMERS-DISEASE, MOUSE MODEL, Biochemistry & Molecular Biology, RNO LS, 1992, PROGRESS IN BRAIN RESEARCH, V94, P429
Subject categories Clinical Medicine

Abstract

Exclusively neuron-centric approaches to neuropathological mechanisms have not resulted in major new breakthroughs in the prevention and therapy of neurodegenerative diseases. In the present paper, we review the role of glia in neurodegeneration in an attempt to identify novel targets that could be used to develop much-needed strategies for the containment and cure of neurodegenerative disorders. We discuss this in the context of glial roles in the homoeostasis and defence of the brain. We consider the mounting evidence supporting a change away from the perception of reactive glial responses merely as secondary detrimental processes that exacerbate the course of neurological disorders, in favour of an emerging contemporary view of glial pathological responses as complex and multistaged defensive processes that also have the potential for dysfunction.

Page Manager: Webmaster|Last update: 9/11/2012
Share:

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?