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Human Norovirus Receptors

Chapter in book
Authors J. Le Pendu
Gustaf E Rydell
Waqas Nasir
Göran Larson
Published in Viral Gastroenteritis: Molecular Epidemiology and Pathogenesis
Pages 379-396
ISBN 978-012802659-5
Publisher Elsevier
Publication year 2016
Published at Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine
Institute of Biomedicine, Department of Infectious Medicine
Pages 379-396
Language en
Links dx.doi.org/10.1016/B978-0-12-802241...
Keywords Glycosphingolipid, HBGA, Norovirus, Receptor, Secretor, VLP
Subject categories Microbiology in the medical area, Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)

Abstract

Due to the lack of cell culture methods, studies of human norovirus receptors have been limited to virus challenge and outbreak studies and in vitro binding studies of virus-like particles (VLPs). Norovirus VLPs recognize glycans from the ABO(H) and Lewis histo-blood group family on glycoproteins and glycosphingolipids in a strain-dependent manner. Host genetic studies have shown that for the clinically dominating strains the binding pattern correlates with susceptibility to infection. Particularly, the so-called nonsecretors, characterized by their lack of expression of ABO(H) structures in the gastrointestinal tract, have been identified as resistant to infections by many strains. In support of a receptor status, norovirus VLPs have been shown to bind to intestinal epithelium expressing ABO(H) epitopes, to intestinal glycosphingolipids carrying ABO(H) epitopes and to induce membrane invaginations, resembling endocytosis intermediates, on model membranes carrying such glycosphingolipids. However, in addition to the ABO(H) structures, the VLPs also recognizes other glycans that could play an important role in virus entry into the host cells. © 2016 Elsevier Inc. All rights reserved.

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