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Astrocyte activation and reactive gliosis-A new target in stroke?

Journal article
Authors Milos Pekny
Ulrika Wilhelmsson
Turgut Tatlisumak
Marcela Pekna
Published in Neuroscience Letters
Volume 689
Pages 45-55
ISSN 0304-3940
Publication year 2019
Published at Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
Pages 45-55
Language en
Links dx.doi.org/10.1016/j.neulet.2018.07...
Keywords Astrocytes, Reactive gliosis, Intermediate filaments (Nanofilaments), GFAP, Vimentin, Nestin, Stroke, fibrillary acidic protein, complement peptide c3a, promotes functional, recovery, regulatory volume decrease, focal cerebral-ischemia, intermediate-filaments, mice deficient, chondroitinase abc, neural, plasticity, cell-volume
Subject categories Neurosciences

Abstract

Stroke is an acute insult to the central nervous system (CNS) that triggers a sequence of responses in the acute, subacute as well as later stages, with prominent involvement of astrocytes. Astrocyte activation and reactive gliosis in the acute stage of stroke limit the tissue damage and contribute to the restoration of homeostasis. Astrocytes also control many aspects of neural plasticity that is the basis for functional recovery. Here, we discuss the concept of intermediate filaments (nanofilaments) and the complement system as two handles on the astrocyte responses to injury that both present attractive opportunities for novel treatment strategies modulating astrocyte functions and reactive gliosis.

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