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Cardiac expression of the microsomal triglyceride transport protein protects the heart function during ischemia

Journal article
Authors Martina Klevstig
M. Arif
M. Mannila
S. Svedlund
Ismena Mardani
Marcus Ståhlman
Linda Andersson
Malin Lindbom
Azra Miljanovic
A. Franco-Cereceda
P. Eriksson
Anders Jeppsson
Li-Ming Gan
Malin Levin
A. Mardinoglu
E. Ehrenborg
Jan Borén
Published in Journal of Molecular and Cellular Cardiology
Volume 137
Pages 1-8
ISSN 0022-2828
Publication year 2019
Published at Institute of Medicine, Department of Molecular and Clinical Medicine
Pages 1-8
Language en
Links dx.doi.org/10.1016/j.yjmcc.2019.09....
Keywords MTTP, Polymorphism, Heart, Expression, Function, apolipoprotein-b, gene, cholesterol, association, secretion, variants, promoter, overexpression, identification, lipoproteins, Cardiovascular System & Cardiology, Cell Biology
Subject categories Cardiac and Cardiovascular Systems

Abstract

Aims: The microsomal triglyceride transport protein (MTTP) is critical for assembly and secretion of apolipoprotein B (apoB)-containing lipoproteins and is most abundant in the liver and intestine. Surprisingly, MTTP is also expressed in the heart. Here we tested the functional relevance of cardiac MTTP expression. Materials and methods: We combined clinical studies, advanced expression analysis of human heart biopsies and analyses in genetically modified mice lacking cardiac expression of the MTTP-A isoform of MTTP. Results: Our results indicate that lower cardiac MTTP expression in humans is associated with structural and perfusion abnormalities in patients with ischemic heart disease. MTTP-A deficiency in mice heart does not affect total MTTP expression, activity or lipid concentration in the heart. Despite this, MTTP-A deficient mice displayed impaired cardiac function after a myocardial infarction. Expression analysis of MTTP indicates that MTTP expression is linked to cardiac function and responses in the heart. Conclusions: Our results indicate that MTTP may play an important role for the heart function in conjunction to ischemic events.

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