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N-CAM exhibits a regulatory function in pathological angiogenesis in oxygen induced retinopathy.

Journal article
Authors Joakim Håkansson
Anders Ståhlberg
Fredrik Wolfhagen Sand
Holger Gerhardt
Henrik Semb
Published in PloS one
Volume 6
Issue 10
Pages e26026
ISSN 1932-6203
Publication year 2011
Published at Institute of Biomedicine, Department of Medical and Clinical Genetics
Institute of Biomedicine, Department of Pathology
Institute of Biomedicine
Pages e26026
Language en
Subject categories Cell and Molecular Biology


Diabetic retinopathy and retinopathy of prematurity are diseases caused by pathological angiogenesis in the retina as a consequence of local hypoxia. The underlying mechanism for epiretinal neovascularization (tuft formation), which contributes to blindness, has yet to be identified. Neural cell adhesion molecule (N-CAM) is expressed by Müller cells and astrocytes, which are in close contact with the retinal vasculature, during normal developmental angiogenesis.

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