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[Autoantibodies against the beta 1-adrenergic receptor in myocarditis and dilated cardiomyopathy: localization of two epitopes]

Journal article
Authors G Wallukat
R Morwinski
Yvonne Magnusson
Johan Hoebeke
A Wollenberger
Published in Zeitschrift für Kardiologie
Volume 81 Suppl 4
Pages 79-83
ISSN 0300-5860
Publication year 1992
Published at Wallenberg Laboratory
Pages 79-83
Language de
Keywords Adrenergic beta-Antagonists, pharmacology, Animals, Autoantibodies, analysis, Binding Sites, Antibody, drug effects, immunology, Cardiomyopathy, Dilated, immunology, Cells, Cultured, Epitopes, immunology, Heart Rate, drug effects, physiology, Humans, Myocardial Contraction, drug effects, physiology, Myocarditis, immunology, Myocardium, immunology, Rats, Rats, Wistar, Receptors, Adrenergic, beta, drug effects, immunology
Subject categories Microbiology in the medical area


Sera of patients with myocarditis and dilated cardiomyopathy contain stimulatory autoantibodies directed specifically against the beta 1-adrenergic receptor. The binding of the antibodies could be localized to either the first or the second extracellular loop of the beta 1-adrenoceptor. In 73% of the cases investigated the antibodies recognized the second extracellular loop. The agonistic effects of the antibodies were abolished by beta-adrenergic antagonists. Furthermore, the antagonists were able to remove the antibodies from their binding sites.

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