To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

Cardiac sympathetic nerve… - University of Gothenburg, Sweden Till startsida
Sitemap
To content Read more about how we use cookies on gu.se

Cardiac sympathetic nerve stimulation triggers coronary t-PA release.

Journal article
Authors Jan-Arne Björkman
Sverker Jern
Christina Jern
Published in Arteriosclerosis, thrombosis, and vascular biology
Volume 23
Issue 6
Pages 1091-7
ISSN 1524-4636
Publication year 2003
Published at Institute of Clinical Neurosciences
Pages 1091-7
Language en
Links dx.doi.org/10.1161/01.ATV.000007296...
Keywords Adrenergic alpha-Agonists, pharmacology, Adrenergic beta-Agonists, pharmacology, Animals, Blood Pressure, drug effects, Calcium Channel Blockers, pharmacology, Coronary Circulation, drug effects, Coronary Vessels, drug effects, secretion, Electric Stimulation, Endothelium, Vascular, drug effects, secretion, Female, Heart, innervation, Heart Rate, drug effects, Hyperemia, physiopathology, Isoproterenol, pharmacology, Male, Nitric Oxide Donors, pharmacology, Nitroprusside, pharmacology, Phenylephrine, pharmacology, Pyridines, pharmacology, Swine, Sympathetic Nervous System, physiology, Tachycardia, physiopathology, Tissue Plasminogen Activator, secretion
Subject categories Medical and Health Sciences

Abstract

OBJECTIVE: This study was undertaken to determine whether stimulation of sympathetic cardiac nerves induces release of the thrombolytic enzyme tissue-type plasminogen activator (t-PA) in the coronary vascular bed. METHODS AND RESULTS: Anesthetized pigs were studied in an open chest model. Bilateral vagotomy was performed, and sympathetic cardiac nerves were activated by electrical stimulation (1 and 8 Hz). To evaluate possible mediating effects of increased heart rate and enhanced local blood flow, tachycardia was induced by pacing and hyperemia by local infusion of sodium nitroprusside and clevedipine. Furthermore, to study the effects of alpha- and beta-adrenergic receptor stimulation, phenylephrine and isoprenaline were infused locally. In response to low- and high-frequency sympathetic stimulation, mean coronary net release of total t-PA increased approximately 6- and 25-fold, respectively. Active t-PA showed a similar response pattern. Neither tachycardia nor coronary hyperemia stimulated t-PA release. In contrast, beta-adrenergic stimulation by isoprenaline induced an approximately 6-fold increase in coronary t-PA release, whereas no significant change in release rates occurred in response to alpha-adrenergic stimulation by phenylephrine. CONCLUSIONS: Stimulation of cardiac sympathetic nerves induces a marked coronary release of t-PA, and part of this response may be mediated through stimulation of beta-adrenergic receptors.

Page Manager: Webmaster|Last update: 9/11/2012
Share:

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?