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CD4(+) regulatory T cells in gastric cancer mucosa are proliferating and express high levels of IL-10 but little TGF-β.

Journal article
Authors Bert Kindlund
Åsa Sjöling
Chakradhar Yakkala
Jenni Adamsson
Anders Janzon
Lars-Erik Hansson
Michael Hermansson
Peter Janson
Ola Winqvist
Samuel B Lundin
Published in Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
Volume 20
Issue 1
ISSN 1436-3291
Publication year 2017
Published at Institute of Biomedicine, Department of Microbiology and Immunology
Language en
Keywords Helicobacter pylori, Gastric cancer, Regulatory T cell, Proliferation, IL-10
Subject categories Surgery, Cancer and Oncology


An increase of regulatory T cells, defined as CD25(high)- and/or FOXP3(+)-expressing CD4(+) T cells, within tumors has been reported in several studies. Tregs promote tumor growth by modulating the antitumor immune response, mainly through inhibition of T-cell-mediated tumor cell killing: this has been suggested to be dependent on IL-10 and/or TGF-β. In stomach cancer, the mechanisms behind the accumulation of Tregs in tumor tissue has not been fully elucidated, and neither has Treg gene expression in situ.

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