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Biofilm formation by Staphylococcus aureus clinical isolates correlates with the infection type.

Journal article
Authors Jakub Kwiecinski
Gunnar Jacobsson
Alexander R Horswill
Elisabet Josefsson
Tao Jin
Published in Infectious diseases
Volume 51
Issue 6
Pages 446-451
ISSN 2374-4243
Publication year 2019
Published at Institute of Medicine, Department of Rheumatology and Inflammation Research
Pages 446-451
Language en
Keywords Biofilm, Staphylococcus aureus, clinical outcome, skin, antibiotic sensitivity, agr
Subject categories Infectious Medicine


Biofilms are involved in many Staphylococcus aureus infections, but relation of biofilm formation and the infection types or the clinical outcomes remain unclear.We measured biofilm formation, with a microtiter plate assay, of a collection of methicillin-sensitive clinical isolates from 159 invasive S. aureus infections, encompassing all cases occurring within a hospital catchment area during two years, and from additional 49 non-invasive skin infections from the same region. Results were related to available clinical and microbiological documentation.Isolates from medical device infections (intravenous line-associated and prosthetic joint infections), as well as isolates from superficial skin infections, were particularly proficient in forming biofilms. No increased biofilm-forming capacity was seen in isolates from endocarditis, osteomyelitis, or other infections. There was also a correlation of biofilm formation with the agr type of the isolates. Thicker biofilms were more resistant to antibiotic treatment in vitro. No correlation between biofilm formation and clinical outcomes was noted.S. aureus isolates from 'classical' biofilm-related infections, but also from superficial skin infections, are especially proficient in forming biofilms. There is, however, no obvious relation of biofilm-forming capacity of isolates and the clinical outcome of the infection, and more studies on this issue are needed.

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