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P-cadherin as a marker in the differential diagnosis of breast lesions.

Journal article
Authors Anikó Kovács
R A Walker
Published in Journal of clinical pathology
Volume 56
Issue 2
Pages 139-41
ISSN 0021-9746
Publication year 2003
Published at Institute of Laboratory Medicine, Dept of Pathology
Pages 139-41
Language en
Keywords Adenocarcinoma, diagnosis, Biomarkers, Tumor, analysis, Breast Diseases, diagnosis, Breast Neoplasms, diagnosis, Cadherins, analysis, Carcinoma, Intraductal, Noninfiltrating, diagnosis, Diagnosis, Differential, Female, Humans, Neoplasm Proteins, analysis
Subject categories Medical Laboratory Science


To assess the value of the calcium dependent cell adhesion molecule P-cadherin as a myoepithelial marker in the differential diagnosis of benign and malignant breast lesions.Immunohistochemical analysis of normal breast, sclerotic breast lesions, tubular carcinomas, and ductal carcinoma in situ using a P-cadherin specific antibody and comparison with smooth muscle actin.All myoepithelial cells in normal breast ducts, ductules, and lobules and sclerotic lesions showed strong staining for P-cadherin. There was no staining of tubular carcinomas; myoepithelial cells were demonstrated around in situ carcinomas. Weaker reactivity was seen in a proportion of cells in some hyperplasias and in situ carcinomas. This weak reactivity in these tissues was not seen for smooth muscle actin but in radial scars, tubular carcinomas, and ductal carcinoma in situ staining of stromal cells caused difficulties in the identification of myoepithelial cells.P-cadherin is a useful marker in the differential diagnosis of breast lesions.

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