To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

Immunogenic neoantigens d… - University of Gothenburg, Sweden Till startsida
To content Read more about how we use cookies on

Immunogenic neoantigens derived from gene fusions stimulate T cell responses

Journal article
Authors W. Yang
K. W. Lee
R. M. Srivastava
F. S. Kuo
C. Krishna
D. Chowell
V. Makarov
D. Hoen
Martin Dalin
L. Wexler
R. Ghossein
N. Katabi
Z. Nadeem
M. A. Cohen
S. K. Tian
N. Robine
K. Arora
H. Geiger
P. Agius
N. Bouvier
K. Huberman
K. Vanness
J. J. Havel
J. S. Sims
R. M. Samstein
R. Mandal
J. Tepe
I. Ganly
A. L. Ho
N. Riaz
R. J. Wong
N. Shukla
T. A. Chan
L. G. T. Morris
Published in Nature Medicine
Volume 25
Issue 5
Pages 767-+
ISSN 1078-8956
Publication year 2019
Published at Institute of Clinical Sciences, Department of Pediatrics
Pages 767-+
Language en
Keywords tumor-antigens, somatic mutations, bcr-abl, cancer, landscape, immunotherapy, induction, peptides, blockade, protein
Subject categories Cancer and Oncology


Anti-tumor immunity is driven by self versus non-self discrimination. Many immunotherapeutic approaches to cancer have taken advantage of tumor neoantigens derived from somatic mutations. Here, we demonstrate that gene fusions are a source of immunogenic neoantigens that can mediate responses to immunotherapy. We identified an exceptional responder with metastatic head and neck cancer who experienced a complete response to immune checkpoint inhibitor therapy, despite a low mutational load and minimal pre-treatment immune infiltration in the tumor. Using whole-genome sequencing and RNA sequencing, we identified a novel gene fusion and demonstrated that it produces a neoantigen that can specifically elicit a host cytotoxic T cell response. In a cohort of head and neck tumors with low mutation burden, minimal immune infiltration and prevalent gene fusions, we also identified gene fusion-derived neoantigens that generate cytotoxic T cell responses. Finally, analyzing additional datasets of fusion-positive cancers, including checkpoint-inhibitor-treated tumors, we found evidence of immune surveillance resulting in negative selective pressure against gene fusion-derived neoantigens. These findings highlight an important class of tumor-specific antigens and have implications for targeting gene fusion events in cancers that would otherwise be less poised for response to immunotherapy, including cancers with low mutational load and minimal immune infiltration.

Page Manager: Webmaster|Last update: 9/11/2012

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?