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Cerebrospinal fluid levels of neurogranin in Parkinsonian disorders.

Journal article
Authors Sara Hall
Shorena Janelidze
Henrik Zetterberg
Britta Brix
Niklas Mattsson
Yulia Surova
Kaj Blennow
Oskar Hansson
Published in Movement disorders : official journal of the Movement Disorder Society
Volume 35
Issue 3
Pages 513-518
ISSN 1531-8257
Publication year 2020
Published at Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Pages 513-518
Language en
Links dx.doi.org/10.1002/mds.27950
www.ncbi.nlm.nih.gov/entrez/query.f...
Subject categories Neurochemistry

Abstract

CSF concentration of neurogranin has been suggested as a biomarker for synapse dysfunction.To investigate CSF neurogranin in parkinsonian disorders compared to controls and Alzheimer's disease and the possible correlations between neurogranin and cognitive and motor impairment.We included 157 patients with PD, 29 with PD with dementia, 11 with dementia with Lewy bodies, 26 with MSA, 21 with PSP, 6 with corticobasal syndrome, 47 controls, and 124 with Alzheimer's disease. CSF neurogranin was measured using two enzyme-linked immunosorbent assays; from EUROIMMUN and the University of Gothenburg.We found a strong correlation between CSF neurogranin-EI and CSF neurogranin-University of Gothenburg (Rs = 0.890; P < 0.001). Neurogranin was decreased in PD, PD with dementia, MSA, and PSP compared to controls and Alzheimer's disease. Neurogranin did not correlate with motor or cognitive impairment, longitudinal decline, or progression to dementia in PD.CSF neurogranin is decreased in parkinsonian disorders compared to controls, emphasizing the importance of synaptic dysfunction in these disorders. © 2019 International Parkinson and Movement Disorder Society.

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