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Antiretroviral treatment for HIV infection: Swedish recommendations 2019

Journal article
Authors J. Eriksen
C. Carlander
J. Albert
L. Flamholc
Magnus Gisslén
L. Naver
V. Svedhem
Aylin Yilmaz
A. Sonnerborg
Published in Infectious Diseases
Volume 52
Issue 5
Pages 295-329
ISSN 2374-4235
Publication year 2020
Published at Institute of Biomedicine, Department of Infectious Medicine
Pages 295-329
Language en
Links dx.doi.org/10.1080/23744235.2019.17...
Keywords Antiretroviral, HIV, treatment guidelines, Sweden, adult, paediatric, tenofovir disoproxil fumarate, cervical intraepithelial neoplasia, human-papillomavirus vaccine, randomized double-blind, once-daily, dolutegravir, public-health agency, short-term risk, initial treatment, hiv-1-infected patients, drug-resistance, Infectious Diseases
Subject categories Infectious Medicine

Abstract

The Swedish Reference Group for Antiviral Therapy (RAV) published recommendations for the treatment of HIV infection in this journal most recently in 2017. An expert group under the guidance of RAV here provides updated recommendations. The most important updates in the present guidelines are the following: (a) The risk of HIV transmission through condomless sex from individuals with fully suppressed HIV viral load is effectively zero. (b) Pre-exposure prophylaxis (PrEP) is recommended for groups with a high risk of HIV infection. (c) Since the last update, two new substances have been registered: bictegravir and doravirine. (d) Dual treatment may be an alternative in selected patients, using lamivudine + dolutegravir or lamivudine + boosted darunavir/atazanavir. As with previous publications, recommendations are evidence-graded in accordance with the Oxford Centre for Evidence Based Medicine. This document does not cover treatment of opportunistic infections and tumours.

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