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Parkinson's disease in diphenyl-exposed workers--a causal association?

Journal article
Authors Gunilla Wastensson
Stig Hagberg
Eva Andersson
Bo Johnels
Lars Barregård
Published in Parkinsonism & Related Disorders
Volume 12
Issue 1
Pages 29-34
Publication year 2006
Published at Institute of Medicine, School of Public Health and Community Medicine
Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
Pages 29-34
Language en
Keywords Parkinson's disease, Diphenyl, Pesticides, Occupational exposure, Paper mill
Subject categories Neurology


We report a cluster of five cases of Parkinson's disease (PD) among paper mill workers exposed to a fungicide, diphenyl. The cause of PD is still unknown, but epidemiological studies have indicated an elevated risk of developing PD after exposure to pesticides. The five cases of PD were found in a group of 255 diphenyl-exposed workers, and the number of expected cases in the exposed group was estimated to be 0.9, resulting in a relative risk of 5.6 (95% CI 1.8-13). Exposure to diphenyl may have contributed to this PD cluster, but chance is an alternative explanation.

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