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A novel in vivo method for quantifying the interfacial biochemical bond strenth of bone implants

Journal article
Authors Young-Taeg Sul
Carina B. Johansson
Tomas Albrektsson
Published in Journal of The Royal Society Interface
Volume 7
Issue 42
Pages 81-90
ISSN 1742-5662
Publication year 2010
Published at Institute of Clinical Sciences, Department of Biomaterials
Pages 81-90
Language en
Keywords Bone implant interface, interfacial biochemical bond, bonding strength measurement, titanium, metal plasma source ion implantation (MePSII), surface property.
Subject categories Industrial Biotechnology, Chemistry, Biomaterials


Quantifying the in vivo interfacial biochemical bond strength of bone implants is a biological challenge. We have developed a new and novel in vivo method to identify an interfacial biochemical bond in bone implants and measure its bonding strength. This method, named BBM (biochemical bond measurement), involves a combination of the implant devices to truly measure interfacial bond strength and surface property controls, and thus enables to distinguish the contributions of mechanical interlocking and biochemical bonding from the measured strength values. We applied the BBM method to a rabbit model, and observed great differences in bone integration between the oxygen (control group) and magnesium (test group) plasma immersion ion implanted titanium implants (0.046 vs. 0.086 MPa, n = 10, P = 0.005). The biochemical bond in the test implants resulted in superior interfacial behavior of the implants to bone: i) close contact to approximately 2 μm thin amorphous interfacial tissue; ii) pronounced mineralization of the interfacial tissue; iii) rapid bone healing in contact; iv) strong integration to bone. The BBM method can be applied to in vivo experimental model not only to validate the presence of a biochemical bond at bone-implant interface but also to measure the relative quantity of biochemical bond strength. The present study may provide new avenues for better understanding the role of a biochemical bond involved in integration of bone implants.

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