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Genetic variation at the BDNF locus: evidence for association with long-term outcome after ischemic stroke.

Journal article
Authors Tara M Stanne
Anna Tjärnlund-Wolf
Sandra Olsson
Katarina Jood
Christian Blomstrand
Christina Jern
Published in PloS one
Volume 9
Issue 12
Pages e114156
ISSN 1932-6203
Publication year 2014
Published at Institute of Biomedicine, Department of Medical and Clinical Genetics
Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
Pages e114156
Language en
Subject categories Neurology


Rates and extent of recovery after stroke vary considerably between individuals and genetic factors are thought to contribute to post-stroke outcome. Brain-derived neurotrophic factor (BDNF) plays important roles in brain plasticity and repair and has been shown to be involved in stroke severity, recovery, and outcome in animal models. Few clinical studies on BDNF genotypes in relation to ischemic stroke have been performed. The aims of the present study are therefore to investigate whether genetic variation at the BDNF locus is associated with initial stroke severity, recovery and/or short-term and long-term functional outcome after ischemic stroke.

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