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Protective effect of bisoprolol on beta-1 adrenoceptor peptide-induced autoimmune myocardial damage in rabbits.

Journal article
Authors S Matsui
M Persson
H M Fu
M Hayase
S Katsuda
K Teraoka
T Kurihara
Michael Fu
Published in Herz
Volume 25
Issue 3
Pages 267-70
ISSN 0340-9937
Publication year 2000
Published at Wallenberg Laboratory
Institute of Internal Medicine
Pages 267-70
Language en
Keywords Adrenergic beta-Antagonists, pharmacology, Animals, Autoimmune Diseases, immunology, pathology, Bisoprolol, pharmacology, Cardiac Volume, drug effects, Cardiomyopathy, Dilated, immunology, pathology, Myocardium, pathology, Rabbits, Receptors, Adrenergic, beta-1, immunology
Subject categories Physiology, Cell and Molecular Biology, Microbiology in the medical area


Idiopathic dilated cardiomyopathy is a severe disease of unknown etiology. Accumulating evidence suggests that agonist-like autoantibodies against the beta 1 adrenoceptor in the circulation of dilated cardiomyopathy may play an important role. The aim of this study was to evaluate the effects of the selective beta 1-adrenoceptor blocker, bisoprolol, on beta 1-adrenoceptor peptide induced autoimmune myocardial damage. In the animal model of autoimmune cardiomyopathy induced by active immunization of rabbits with beta 1-adrenoceptor peptide, bisoprolol was given at a dose of 3 mg/day throughout the study period. Our results showed high titer of anti-beta 1-adrenoceptor antibody in the immunized group throughout the study but not in the group receiving only bisoprolol. Cross-reactivity to beta 2 adrenoceptors was observed in some of the immunized rabbits, but disappeared almost entirely after 6 months. As compared to the beta 1-adrenoceptor peptide immunized group without bisoprolol treatment, bisoprolol treated beta 1-receptor peptide immunized group showed increase in the wall thickness and decreases in cavity dimension in anatomical measurements and only mild alterations in macro- and microscopic examinations. Thus, our study clearly demonstrated a beneficial effect of bisoprolol in rabbits who have developed autoimmune myocardial damage.

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