To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

Hypoxic preconditioning c… - University of Gothenburg, Sweden Till startsida
Sitemap
To content Read more about how we use cookies on gu.se

Contact form








 


Note! If you want an answer on a question you must specify your email address




Hypoxic preconditioning confers long-term reduction of brain injury and improvement of neurological ability in immature rats

Journal article
Authors Malin Gustavsson
Michelle F Anderson
Carina Mallard
Henrik Hagberg
Published in Pediatr Res
Volume 57
Issue 2
Pages 305-9
Publication year 2005
Published at Institute for the Health of Women and Children, Dept of Obstetrics and Gynaecology
Institute of Physiology and Pharmacology, Dept of Physiology
Pages 305-9
Language en
Links www.ncbi.nlm.nih.gov/entrez/query.f...
Keywords Animals, Animals, Newborn, *Anoxia, Brain Damage, Chronic/prevention & control, Brain Injuries/*prevention & control, Brain Ischemia/*pathology, Hypoxia-Ischemia, Brain, Ischemic Preconditioning, Maze Learning, Oxygen/metabolism, Rats, Rats, Sprague-Dawley, Time Factors
Subject categories Experimental brain research

Abstract

Exposure to preconditioning (PC) hypoxia 24 h before a severe hypoxic-ischemic (HI) insult reduces development of injury in the immature brain. Several protective regimens have proved effective in the short-term but not in the long-term perspective. The aim of the present study, therefore, was to evaluate the PC effect on long-term morphologic and neurologic outcome in the developing brain. Six-day-old rats were subjected to hypoxia (36 degrees C, 8.0% O2; PC/HI group) and sham controls to normoxia (36 degrees C; HI group) for 3 h. Twenty-four hours later, all rats were exposed to cerebral HI produced by unilateral carotid artery occlusion combined with 1 h, 15 min of hypoxia (36 degrees C, 7.7% O2). A cylinder test was used to evaluate forelimb asymmetry to determine sensorimotor function at 4, 6, and 8 wk of age. Spatial/cognitive ability was assessed by Morris water maze trials at 7 wk of recovery. Neuropathologic analysis was performed 8 wk after insult. Brain damage was reduced (p<0.0001) in PC/HI (45.0+/-11.1 mm3) in comparison with HI (159.3+/-12.2 mm3) rats. A bias for using the ipsilateral forelimb in wall movements was observed in the cylinder test in HI compared with PC/HI rats at 4 (p<0.001), 6 (p<0.01), and 8 (p<0.0001) wk of age. Results of the Morris water maze test revealed differences (p<0.0001) in average path length between groups on the third and fourth day of trials. Hypoxic PC before HI reduced brain injury by 72% at 8 wk after the insult and provided long-term improvement of sensorimotor and spatial/cognitive functions.

Page Manager: Webmaster|Last update: 9/11/2012
Share:

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?

Denna text är utskriven från följande webbsida:
http://gu.se/english/research/publication/?feedbackForm=true&returnAddress=http%3A%2F%2Fgu.se%2Fenglish%2Fresearch%2Fpublication%2F%3FpublicationId%3D48931&recipientName=Webmaster&encodedEmail=YW5uaWthLmtvbGRlbml1c0BndS5zZQ&publicationId=48931
Utskriftsdatum: 2020-02-17