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Pyrosequencing of Antibiotic-Contaminated River Sediments Reveals High Levels of Resistance and Gene Transfer Elements

Journal article
Authors Erik Kristiansson
J. Fick
Anders Janzon
R. Grabic
Carolin Rutgersson
Birgitta Weijdegård
H. Soderstrom
D. G. Joakim Larsson
Published in Plos One
Volume 6
Issue 2
ISSN 1932-6203
Publication year 2011
Published at Institute of Neuroscience and Physiology, Department of Physiology
Department of Mathematical Sciences, Mathematical Statistics
Language en
Links dx.doi.org/10.1371/journal.pone.001...
https://gup.ub.gu.se/file/65230
Keywords mediated quinolone resistance, aquatic environment, bacteria, soil, diversity, integrons, database, water, identification, metagenomics
Subject categories Biological Sciences

Abstract

The high and sometimes inappropriate use of antibiotics has accelerated the development of antibiotic resistance, creating a major challenge for the sustainable treatment of infections world-wide. Bacterial communities often respond to antibiotic selection pressure by acquiring resistance genes, i.e. mobile genetic elements that can be shared horizontally between species. Environmental microbial communities maintain diverse collections of resistance genes, which can be mobilized into pathogenic bacteria. Recently, exceptional environmental releases of antibiotics have been documented, but the effects on the promotion of resistance genes and the potential for horizontal gene transfer have yet received limited attention. In this study, we have used culture-independent shotgun metagenomics to investigate microbial communities in river sediments exposed to waste water from the production of antibiotics in India. Our analysis identified very high levels of several classes of resistance genes as well as elements for horizontal gene transfer, including integrons, transposons and plasmids. In addition, two abundant previously uncharacterized resistance plasmids were identified. The results suggest that antibiotic contamination plays a role in the promotion of resistance genes and their mobilization from environmental microbes to other species and eventually to human pathogens. The entire life-cycle of antibiotic substances, both before, under and after usage, should therefore be considered to fully evaluate their role in the promotion of resistance.

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Denna text är utskriven från följande webbsida:
http://gu.se/english/research/publication/?publicationId=138477
Utskriftsdatum: 2020-04-04