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The association between plasma homocysteine and coronary heart disease is modified by the MTHFR 677C>T polymorphism.

Journal article
Authors Kirsten Mehlig
K Leander
U de Faire
Fredrik Nyberg
Christina Berg
Annika Rosengren
Lena Björck
Henrik Zetterberg
Kaj Blennow
Gianluca Tognon
Kjell Torén
Elisabeth Strandhagen
Lauren Lissner
Dag Thelle
Published in Heart (British Cardiac Society)
Volume 99
Issue 23
Pages 1761-1765
ISSN 1468-201X
Publication year 2013
Published at Institute of Medicine, School of Public Health and Community Medicine
Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Krefting Research Centre
Department of Food and Nutrition, and Sport Science
Institute of Medicine, Department of Molecular and Clinical Medicine
Pages 1761-1765
Language en
Subject categories Public Health, Global Health, Social Medicine and Epidemiology


An elevated level of total plasma homocysteine (tHcy) has been associated with risk of coronary heart disease (CHD). The level of tHcy is affected by lifestyle, in addition to genetic predisposition. The methylene tetrahydrofolate reductase (MTHFR) 677C>T polymorphism (rs1801133) is among the strongest genetic predictors of tHcy. We examined whether the association between tHcy and CHD is modified by the MTHFR 677C>T polymorphism.

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Utskriftsdatum: 2020-08-04