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Effects of aerobic and resistance exercise in older adults with rheumatoid arthritis: A randomized controlled trial.

Journal article
Authors Elvira Lange
Daniel Kucharski
Sara Svedlund
Karin Svensson
Gunhild Bertholds
Inger Gjertsson
Kaisa Mannerkorpi
Published in Arthritis care & research
Volume 71
Issue 1
Pages 61-70
ISSN 2151-4658
Publication year 2019
Published at Institute of Neuroscience and Physiology, Department of Health and Rehabilitation
University of Gothenburg Centre for person-centred care (GPCC)
Institute of Medicine, Department of Rheumatology and Inflammation Research
Institute of Medicine, Department of Molecular and Clinical Medicine
Pages 61-70
Language en
Subject categories Physiotherapy


To evaluate the effect of a person-centered, moderate-to-high intensity, aerobic and resistance exercise protocol on older adults with rheumatoid arthritis (RA), through a randomized controlled multi-center trial.Older adults (65-75 years) with RA (n=74) were randomized to either a 20-week person-centered exercise intervention at a gym (n=36) or to home-based exercise of light intensity (n=38). Assessments were performed at baseline, at 20 weeks, and at 12 months. Primary outcome was the difference in the Health Assessment Questionnaire - Disability Index (HAQ-DI), and the secondary outcomes were the differences in physical fitness assessed by a cardiopulmonary exercise test, an endurance test, Timed Up and Go, Sit To Stand test and isometric elbow flexion force.No significant differences between the groups were found for the primary outcome HAQ-DI. Within the intervention group there was a significant improvement of HAQ-DI when compared to baseline (p=0.022). Aerobic capacity (p<0.001) and three out of four additional performance-based tests of endurance and strength significantly improved (p<0.05) in the intervention group when compared to the control group. In the intervention group 71% rated their health as much or very much improved compared to 24% of the control group (p<0.001). At the 12-month follow-up, there were no significant difference of change between the two groups on HAQ-DI. A significant between-group difference was found for change in an endurance test (p=0.022).Person-centered aerobic and resistance exercise improved physical fitness in terms of aerobic capacity, endurance and strength in older adults with RA. This article is protected by copyright. All rights reserved.

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Utskriftsdatum: 2020-01-26