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Spatiotemporal segregation of human marginal zone and memory B cell populations in lymphoid tissue.

Journal article
Authors Yuan Zhao
Mohamed Uduman
Jacqueline H Y Siu
Thomas J Tull
Jeremy D Sanderson
Yu-Chang Bryan Wu
Julian Q Zhou
Nedyalko Petrov
Richard Ellis
Katrina Todd
Konstantia-Maria Chavele
William Guesdon
Anna Vossenkamper
Wayel Jassem
David P D'Cruz
David J Fear
Susan John
Dagmar Scheel-Toellner
Claire Hopkins
Estefania Moreno
Natalie L Woodman
Francesca Ciccarelli
Susanne Heck
Steven H Kleinstein
Mats Bemark
Jo Spencer
Published in Nature communications
Volume 9
Issue 1
Pages 3857
ISSN 2041-1723
Publication year 2018
Published at Institute of Biomedicine, Department of Microbiology and Immunology
Pages 3857
Language en
Links dx.doi.org/10.1038/s41467-018-06089...
www.ncbi.nlm.nih.gov/entrez/query.f...
Subject categories Immunobiology, Immunology

Abstract

Human memory B cells and marginal zone (MZ) B cells share common features such as the expression of CD27 and somatic mutations in their IGHV and BCL6 genes, but the relationship between them is controversial. Here, we show phenotypic progression within lymphoid tissues as MZ B cells emerge from the mature naïve B cell pool via a precursor CD27-CD45RBMEM55+ population distant from memory cells. By imaging mass cytometry, we find that MZ B cells and memory B cells occupy different microanatomical niches in organised gut lymphoid tissues. Both populations disseminate widely between distant lymphoid tissues and blood, and both diversify their IGHV repertoire in gut germinal centres (GC), but nevertheless remain largely clonally separate. MZ B cells are therefore not developmentally contiguous with or analogous to classical memory B cells despite their shared ability to transit through GC, where somatic mutations are acquired.

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Denna text är utskriven från följande webbsida:
http://gu.se/english/research/publication/?publicationId=270987
Utskriftsdatum: 2019-10-24