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Apathy and anxiety are early markers of Alzheimer's disease

Journal article
Authors M. Johansson
E. Stomrud
O. Lindberg
E. Westman
Per Mårten Johansson
D. van Westen
N. Mattsson
O. Hansson
Published in Neurobiology of Aging
Volume 85
Pages 74-82
ISSN 0197-4580
Publication year 2020
Published at Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
Pages 74-82
Language en
Keywords Apathy, Anxiety, Amyloid, Alzheimer's disease, White matter lesions, Imaging, mild cognitive impairment, white-matter hyperintensities, incident, depressive symptoms, cortical amyloid deposition, brain, burden, beta, decline, scale, mri, Geriatrics & Gerontology, Neurosciences & Neurology
Subject categories Neurobiology


In this study, we investigated associations between neuropsychiatric symptoms (i.e., apathy, anxiety, and depression) and cerebral atrophy, white matter lesions (WML), beta-amyloid (A beta) deposition, and cognitive decline in a nondemented sample. 104 cognitively unimpaired and 53 subjects with mild cognitive impairment were followed for up to 4 years within the Swedish BioFINDER study. Neuropsychiatric assessments included the Hospital Anxiety and Depression Scale and the Apathy Evaluation Scale. Magnetic resonance imaging and F-18-flutemetamol-positron emission tomography quantified brain atrophy, WML, and A beta deposition. Mini-Mental State Examination assessed longitudinal global cognition. Regression analyses were used to test for associations. Apathy and anxiety were shown related to A beta deposition and predicted cognitive decline. Anxiety also interacted with amyloid status to predict faster cognitive deterioration. Apathy was further related to frontotemporal and subcortical atrophy, as well as WML. To conclude, the associations between apathy and anxiety with A beta deposition and cognitive decline point to these symptoms as early clinical manifestations of Alzheimer's disease. (C) 2019 Elsevier Inc. All rights reserved.

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Utskriftsdatum: 2020-03-31