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Clara cell protein as a biomarker for lung epithelial injury in asphalt workers.

Journal article
Authors Bente Ulvestad
Britt Grethe Randem
Lena Andersson
Dag G Ellingsen
Lars Barregård
Published in Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine
Volume 49
Issue 10
Pages 1073-8
ISSN 1076-2752
Publication year 2007
Published at Institute of Medicine, School of Public Health and Community Medicine
Pages 1073-8
Language en
Keywords Biological Markers, Epithelial Cells, pathology, Epithelium, Humans, Hydrocarbons, adverse effects, Lung, pathology, Lung Injury, Middle Aged, Norway, Occupational Exposure, adverse effects, Questionnaires, Uteroglobin, analysis, blood
Subject categories Toxicology, Dermatology and Venereal Diseases


OBJECTIVE: We investigated if asphalt workers showed signs of lung epithelial injury as shown by increased Clara cell protein 16 (CC16) in serum after 6 months of exposure. METHODS: Asphalt pavers, asphalt plant operators, and asphalt engineers underwent lung function tests and blood samples before the start of the asphalt season. The tests were repeated before the end of the asphalt season. Blood samples were analyzed for concentration of CC16 and interleukin-6 (IL-6). RESULTS: After adjustment for current smoking, the pavers had a significantly larger increase in CC16 concentrations after the season as compared with that of the engineers and plant operators. In pavers, the change in serum CC16 was correlated with the change in IL-6. CONCLUSION: CC16 increased over the season in pavers and appears to be a useful biomarker for lung epithelial injury in exposed workers.

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