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Protein profiling identified dissociations between growth hormone-mediated longitudinal growth and bone mineralization in short prepubertal children

Journal article
Authors Björn Andersson
Ralph Decker
Andreas F M Nierop
Ingvar Bosaeus
Kerstin Albertsson-Wikland
Gunnel Hellgren
Published in Journal of Proteomics
Volume 74
Issue 1
Pages 89–100
ISSN 1876-7737
Publication year 2011
Published at Institute of Medicine, Department of Clinical Nutrition
Institute of Clinical Sciences, Department of Pediatrics
Pages 89–100
Language en
Links dx.doi.org/10.1016/j.jprot.2010.08....
Keywords Proteomics, bone mineral content, bone mineralization, biomarkers, growth
Subject categories Clinical pharmacology, Clinical physiology

Abstract

Growth hormone (GH) promotes longitudinal growth and bone mineralization. In this study, a proteomic approach was used to analyze the association between serum protein expression pattern and height-adjusted bone mineralization in short prepubertal children receiving GH treatment. Patterns of protein expression were compared with those associated with longitudinal bone growth. Specific protein expression patterns associated with changes in height-adjusted bone mineralization in response to GH treatment were identified. Out of the 37 peaks found in significant regression models, 27 were uniquely present in models correlated with changes in bone mineralization and 7 peaks were uniquely present in models correlated with changes in height. The peaks identified corresponded to apolipoproteins, transthyretin, serum amyloid A4 and hemoglobin beta. We conclude that a proteomic approach could be used to identify specific protein expression patterns associated with bone mineralization in response to GH treatment and that height-adjusted bone mineralization and longitudinal bone growth are regulated partly by the same and partly by different mechanisms. Protein isoforms with different post-translational modifications might be of importance in the regulation of these processes. However, further validation is needed to assess the clinical significance of the results.

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