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N-CAM exhibits a regulatory function in pathological angiogenesis in oxygen induced retinopathy.

Journal article
Authors Joakim Håkansson
Anders Ståhlberg
Fredrik Wolfhagen Sand
Holger Gerhardt
Henrik Semb
Published in PloS one
Volume 6
Issue 10
Pages e26026
ISSN 1932-6203
Publication year 2011
Published at Institute of Biomedicine, Department of Medical and Clinical Genetics
Institute of Biomedicine, Department of Pathology
Institute of Biomedicine
Pages e26026
Language en
Links dx.doi.org/10.1371/journal.pone.002...
Subject categories Cell and Molecular Biology

Abstract

Diabetic retinopathy and retinopathy of prematurity are diseases caused by pathological angiogenesis in the retina as a consequence of local hypoxia. The underlying mechanism for epiretinal neovascularization (tuft formation), which contributes to blindness, has yet to be identified. Neural cell adhesion molecule (N-CAM) is expressed by Müller cells and astrocytes, which are in close contact with the retinal vasculature, during normal developmental angiogenesis.

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