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High serum total cholesterol is a long-term cause of osteoporotic fracture.

Journal article
Authors Penelope Trimpou
Anders Odén
Tomas Simonsson
Lars Wilhelmsen
Kerstin Landin-Wilhelmsen
Published in Osteoporosis international
Volume 22
Issue 5
Pages 1615-20
ISSN 0937-941X
Publication year 2011
Published at Department of Mathematical Sciences, Mathematical Statistics
Institute of Medicine, Department of Emergeny and Cardiovascular Medicine
Institute of Medicine, Department of Internal Medicine
Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
Pages 1615-20
Language en
Links dx.doi.org/10.1007/s00198-010-1367-...
Keywords Adult, Anthropometry, methods, Cholesterol, blood, Coffee, adverse effects, Epidemiologic Methods, Female, Humans, Life Style, Male, Middle Aged, Motor Activity, Osteoporotic Fractures, blood, epidemiology, etiology, Recurrence, Smoking, adverse effects, epidemiology, Sweden, epidemiology
Subject categories Medical and Health Sciences, Dermatology and Venereal Diseases

Abstract

Risk factors for osteoporotic fractures were evaluated in 1,396 men and women for a period of 20 years. Serum total cholesterol was found to be an independent osteoporotic fracture risk factor whose predictive power improves with time. The purpose of this study was to evaluate long-term risk factors for osteoporotic fracture. A population random sample of men and women aged 25-64 years (the Gothenburg WHO MONICA project, N = 1,396, 53% women) was studied prospectively. The 1985 baseline examination recorded physical activity at work and during leisure time, psychological stress, smoking habits, coffee consumption, BMI, waist/hip ratio, blood pressure, total, HDL and LDL cholesterol, triglycerides, and fibrinogen. Osteoporotic fractures over a period of 20 years were retrieved from the Gothenburg hospital registers. Poisson regression was used to analyze the predictive power for osteoporotic fracture of each risk factor. A total number of 258 osteoporotic fractures occurred in 143 participants (10.2%). As expected, we found that previous fracture, smoking, coffee consumption, and lower BMI each increase the risk for osteoporotic fracture independently of age and sex. More unexpectedly, we found that the gradient of risk of serum total cholesterol to predict osteoporotic fracture significantly increases over time (p = 0.0377). Serum total cholesterol is an independent osteoporotic fracture risk factor whose predictive power improves with time. High serum total cholesterol is a long-term cause of osteoporotic fracture.

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