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PAQR-2 Regulates Fatty Acid Desaturation during Cold Adaptation in C. elegans

Journal article
Authors Emma Svensk
Marcus Ståhlman
Carl-Henrik Andersson
Maja Johansson
Jan Borén
Marc Pilon
Published in Plos Genetics
Volume 9
Issue 9
ISSN 1553-7404
Publication year 2013
Published at Department of Chemistry and Molecular Biology
Institute of Medicine, Department of Molecular and Clinical Medicine
Language en
Links dx.doi.org/10.1371/journal.pgen.100...
Keywords CAENORHABDITIS-ELEGANS, DROSOPHILA-MELANOGASTER, BIOLOGICAL-MEMBRANES, MASS-SPECTROMETRY, ADIPONECTIN, TOLERANCE, IDENTIFICATION, TEMPERATURE, MECHANISMS, HYPOTHESIS, LCH J, 1957, JOURNAL OF BIOLOGICAL CHEMISTRY, V226, P497
Subject categories Clinical Medicine

Abstract

C. elegans PAQR-2 is homologous to the insulin-sensitizing adiponectin receptors in mammals, and essential for adaptation to growth at 15 degrees C, a low but usually acceptable temperature for this organism. By screening for novel paqr-2 suppressors, we identified mutations in genes involved in phosphatidylcholine synthesis (cept-1, pcyt-1 and sams-1) and fatty acid metabolism (ech-7, hacd-1, mdt-15, nhr-49 and sbp-1). We then show genetic evidence that paqr-2, phosphatidylcholines, sbp-1 and Delta 9-desaturases form a cold adaptation pathway that regulates the increase in unsaturated fatty acids necessary to retain membrane fluidity at low temperatures. This model is supported by the observations that the paqr-2 suppressors normalize the levels of saturated fatty acids, and that low concentrations of detergents that increase membrane fluidity can rescue the paqr-2 mutant.

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