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Expression of High Mobility Group A proteins in oral leukoplakia

Journal article
Authors Lena Larsson
Fredrik Jäwert
Bengt Magnusson
Bengt Hasséus
Göran Kjeller
Published in Anticancer Research
Volume 33
Issue 10
Pages 4261-4266
ISSN 0250-7005
Publication year 2013
Published at Institute of Odontology
Pages 4261-4266
Language en
Keywords leukoplakia, oral cancer, HMGA
Subject categories Oral pathology and forensic odontology


Background: Oral leukoplakia (LPL) is considered a potentially malignant disorder in the oral cavity and the gastric tract. The high mobility group A (HMGA) proteins are important in the transformation of normal cells into cancer cells, but there is a lack of knowledge about their importance in development of oral cancer. The aim of the current project was to investigate HMGA expression in LPLs with different levels of dysplasia. Materials and Methods: Biopsies were histologically processed to visualize the expression of HMGA1 and HMGA2 using immunohistochemistry. Results: An increase of HMGA1-positive cells correlating to the degree of dysplasia was registered in the epithelium and in the connective tissue. HMGA2 expression was seen in the epithelium and in the connective tissue but with no obvious correlation to the level of dysplasia. Conclusion: This is, to our knowledge, the first study showing the expression of HMGA proteins in healthy and non-healthy oral mucosa.

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