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BacMet: antibacterial biocide and metal resistance genes database

Journal article
Authors Chandan Pal
Johan Bengtsson-Palme
Christopher Rensing
Erik Kristiansson
D. G. Joakim Larsson
Published in Nucleic Acids Research
Volume 42
Issue D1
Pages D737-D743
ISSN 0305-1048
Publication year 2014
Published at Department of Mathematical Sciences, Mathematical Statistics
Institute of Biomedicine, Department of Infectious Medicine
Pages D737-D743
Language en
Links dx.doi.org/10.1093/nar/gkt1252
https://gup.ub.gu.se/file/151382
Subject categories Bioinformatics (Computational Biology), Biological Sciences

Abstract

Antibiotic resistance has become a major human health concern due to widespread use, misuse and overuse of antibiotics. In addition to antibiotics, antibacterial biocides and metals can contribute to the development and maintenance of antibiotic resistance in bacterial communities through co-selection. Information on metal and biocide resistance genes, including their sequences and molecular functions, is, however, scattered. Here, we introduce BacMet (http://bacmet.biomedicine.gu.se)-a manually curated database of antibacterial biocide-and metal-resistance genes based on an in-depth review of the scientific literature. The BacMet database contains 470 experimentally verified resistance genes. In addition, the database also contains 25 477 potential resistance genes collected from public sequence repositories. All resistance genes in the BacMet database have been organized according to their molecular function and induced resistance phenotype.

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