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Cadmium exposure, intercellular adhesion molecule-1 and peripheral artery disease: a cohort and an experimental study.

Journal article
Authors Björn Fagerberg
Göran Bergström
Jan Borén
Lars Barregård
Published in BMJ open
Volume 3
Issue 3
ISSN 2044-6055
Publication year 2013
Published at Wallenberg Laboratory
Institute of Medicine, Department of Public Health and Community Medicine, Section of Occupational and environmental medicine
Institute of Medicine, Department of Molecular and Clinical Medicine
Language en
Links dx.doi.org/10.1136/bmjopen-2012-002...
https://gup.ub.gu.se/file/125020
Subject categories Clinical Medicine

Abstract

Cadmium exposure has been found to be associated with atherosclerotic plaques in the carotid arteries and with circulating levels of the proatherogenic intercellular adhesion molecule-1 (ICAM-1). The research questions were (1) if blood and urinary cadmium levels are associated with low ankle-brachial index (ABI) as a measure of peripheral artery disease in a longitudinal study and (2) if ICAM-1 mediates proatherogenic effects of cadmium exposure.

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