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Cell Senescence in Myxoid/Round Cell Liposarcoma

Journal article
Authors Christina Kåbjörn-Gustafsson
Anders Ståhlberg
Katarina Engström
Anna Danielsson
Ingela Turesson
Pierre Åman
Published in Sarcoma
Volume 2014
Issue Article ID 208786
Pages 7 pages
ISSN 1357-714X
Publication year 2014
Published at Institute of Clinical Sciences, Department of Oncology
Institute of Biomedicine, Department of Pathology
Pages 7 pages
Language en
Links dx.doi.org/10.1155/2014/208786
Keywords Senescence, Sarcoma
Subject categories Basic Medicine, Pathology

Abstract

Myxoid/round cell liposarcoma (MLS/RCLS) is the second most common liposarcoma type and characterized by the fusion oncogenes FUS-DDIT3 or EWSR1-DDIT3. Previous analysis of cell cycle regulatory proteins revealed a prominent expression of G1-cyclins, cyclin dependent kinases and their inhibitors but very few cells progressing through the G1/S boundary. Here, we extend the investigation to proteins involved in cell senescence in an immunohistochemistry based study of 17 MLS/RCLS cases. Large subpopulations of tumor cells expressed the RBL2 pocket protein and senescence associated heterochromatin 1γ and IL8 receptor β. We conclude that MLS/RCLS tissues contain major populations of senescent tumor cells and this may explain the slow growth rate of this tumor type.

Page Manager: Webmaster|Last update: 9/11/2012
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