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Identification of enterotoxigenic Escherichia coli (ETEC) clades with long-term global distribution

Journal article
Authors Astrid von Mentzer
T. R. Connor
L. H. Wieler
T. Semmler
A. Iguchi
N. R. Thomson
D. A. Rasko
Enrique Joffre
J. Corander
D. Pickard
Gudrun Wiklund
Ann-Mari Svennerholm
Åsa Sjöling
G. Dougan
Published in Nature Genetics
Volume 46
Issue 12
Pages 1321-1326
ISSN 1061-4036
Publication year 2014
Published at Institute of Biomedicine, Department of Microbiology and Immunology
Pages 1321-1326
Language en
Links dx.doi.org/10.1038/ng.3145
Keywords COLONIZATION FACTOR, VIRULENCE FACTORS, STRAINS, DIARRHEA, TRANSMISSION, EPIDEMIOLOGY, EXPRESSION, EVOLUTION, COUNTRIES, PLASMIDS, Genetics & Heredity
Subject categories Clinical Medicine

Abstract

Enterotoxigenic Escherichia coil (ETEC), a major cause of infectious diarrhea, produce heat-stable and/or heat-labile enterotoxins and at least 25 different colonization factors that target the intestinal mucosa. The genes encoding the enterotoxins and most of the colonization factors are located on plasmids found across diverse E. coli serogroups. Whole-genome sequencing of a representative collection of ETEC isolated between 1980 and 2011 identified globally distributed lineages characterized by distinct colonization factor and enterotoxin profiles. Contrary to current notions, these relatively recently emerged lineages might harbor chromosome and plasmid combinations that optimize fitness and transmissibility. These data have implications for understanding, tracking and possibly preventing ETEC disease.

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