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Atrial fibrillation in patients admitted to coronary care units in western Sweden - focus on obesity and lipotoxicity.

Journal article
Authors Sigfus Gizurarson
Marcus Ståhlman
Anders Jeppsson
Yangzhen Shao
Björn Redfors
Lennart Bergfeldt
Jan Borén
Elmir Omerovic
Published in Journal of electrocardiology
Volume 48
Issue 5
Pages 853-60
ISSN 1532-8430
Publication year 2015
Published at Institute of Medicine, Department of Molecular and Clinical Medicine
Pages 853-60
Language en
Links dx.doi.org/10.1016/j.jelectrocard.2...
Subject categories Cardiovascular medicine

Abstract

Atrial fibrillation (AF) is the most common form of arrhythmia in humans and is associated with substantial morbidity and mortality. Obesity and diabetes have been linked to myocardial lipotoxicity - a condition where the heart accumulates and produces toxic lipid species. We hypothesized that obesity and diabetes were involved in the pathophysiology of AF by means of promoting a lipotoxic phenotype in atrial muscle, and that AF predicts mortality in cardiac care patients.

Page Manager: Webmaster|Last update: 9/11/2012
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