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Regulation of body fat mass by the gut microbiota: Possible mediation by the brain.

Review article
Authors Erik Schéle
Louise Grahnemo
Fredrik Anesten
Anna Hallén
Fredrik Bäckhed
John-Olov Jansson
Published in Peptides
Volume 77
Pages 54–59
ISSN 1873-5169
Publication year 2016
Published at Wallenberg Laboratory
Institute of Neuroscience and Physiology, Department of Physiology
Institute of Medicine, Department of Molecular and Clinical Medicine
Pages 54–59
Language en
Keywords Obesity; Gut microbiota; BDNF; GLP-1
Subject categories Physiology, Neurobiology


New insight suggests gut microbiota as a component in energy balance. However, the underlying mechanisms by which gut microbiota can impact metabolic regulation is unclear. A recent study from our lab shows, for the first time, a link between gut microbiota and energy balance circuitries in the hypothalamus and brainstem. In this article we will review this study further.

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