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Albumin and depression in elderly stroke survivors: An observational cohort study

Journal article
Authors Michaela C. Pascoe
Ingmar Skoog
Christian Blomstrand
Thomas Lindén
Published in Psychiatry Research
Volume 230
Issue 2
Pages 658-63
ISSN 0165-1781
Publication year 2015
Published at Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Pages 658-63
Language en
Keywords Depression; Old age; Outcome; Risk factors; Stroke
Subject categories Other Medical Sciences


Abstract BACKGROUND/OBJECTIVES: Post-stroke depression affects approximately one third of stroke survivors. In non-stroke affected populations, depressive symptomatology is associated with hypoalbuminemia. This is also common among stroke survivors and associated with poor outcome and increased mortality. The role of stroke-associated hypoalbuminemia in post-stroke depression is not clear. We aimed to explore the relationship between serum albumin and post-stroke depression, as measured 20 months post-stroke. SUBJECTS/METHODS: Observational cohort study of elderly Swedish patients drawn from the 'Gothenburg 70+ Stroke Study' (n=149) and assessed at 20 months after stroke onset. Serum albumin was drawn from venous blood and analysed with gas chromatography/mass spectrometry. Depressive symptomatology was assessed using the Montgomery-Åsberg Depression Rating Scale (MADRS) and functional impairment was assessed using the Barthel Index. RESULTS: Analysis of covariance analysis showed that serum albumin levels were associated with depressive symptoms at 20 months after stroke. Multivariate analysis of covariance showed that disability scores at 3 days were associated with depressive symptoms at 20 months after stroke and after accounting for the age covariate. Stroke survivors were not clinically deficient in serum albumin. CONCLUSIONS: Low serum albumin appears to be associated with depressive symptoms in elderly individuals long term post-stroke

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