To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

Kinetic Studies to Elucid… - University of Gothenburg, Sweden Till startsida
Sitemap
To content Read more about how we use cookies on gu.se

Kinetic Studies to Elucidate Impaired Metabolism of Triglyceride-rich Lipoproteins in Humans.

Journal article
Authors Martin Adiels
Adil Mardinoglu
Marja-Riitta Taskinen
Jan Borén
Published in Frontiers in Physiology
Volume 6
Pages 342
ISSN 1664-042X
Publication year 2015
Published at Wallenberg Laboratory
Institute of Medicine, Department of Molecular and Clinical Medicine
Institute of Medicine, Department of Public Health and Community Medicine, Health Metrics
Pages 342
Language en
Links dx.doi.org/10.3389/fphys.2015.00342
https://gup.ub.gu.se/file/178087
Keywords very low density lipoproteins, apoB, multocomnpartmental modeling, kinetics, stable isotopes
Subject categories Bioinformatics (Computational Biology), Bioinformatics and Systems Biology, Basic Medicine, Clinical Medicine

Abstract

To develop novel strategies for prevention and treatment of dyslipidemia, it is essential to understand the pathophysiology of dyslipoproteinemia in humans. Lipoprotein metabolism is a complex system in which abnormal concentrations of various lipoprotein particles can result from alterations in their rates of production, conversion, and/or catabolism. Traditional methods that measure plasma lipoprotein concentrations only provide static estimates of lipoprotein metabolism and hence limited mechanistic information. By contrast, the use of tracers labeled with stable isotopes and mathematical modeling, provides us with a powerful tool for probing lipid and lipoprotein kinetics in vivo and furthering our understanding of the pathogenesis of dyslipoproteinemia.

Page Manager: Webmaster|Last update: 9/11/2012
Share:

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?