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7-(Benzofuran-2-yl)-7-deazadeoxyguanosine as a fluorescence turn-ON probe for single-strand DNA binding protein

Journal article
Authors M. Tokugawa
Y. Masaki
J. C. Canggadibrata
K. Kaneko
T. Shiozawa
T. Kanamori
Morten Grøtli
Marcus Wilhelmsson
M. Sekine
K. Seio
Published in Chemical Communications
Volume 52
Issue 19
Pages 3809-3812
ISSN 1359-7345
Publication year 2016
Published at Department of Chemistry and Molecular Biology
Pages 3809-3812
Language en
Links dx.doi.org/10.1039/c5cc09700b
Subject categories Chemical Sciences, Bioorganic chemistry, Biophysical chemistry, Spectroscopy

Abstract

7-(Benzofuran-2-yl)-7-deazadeoxyguanosine ((BF)dG) was synthesized and incorporated into an oligodeoxynucleotide (ODN). The single-stranded ODN containing (BF)dG shows 91-fold fluorescence enhancement upon binding of single-strand DNA binding protein.

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