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Journal article
Authors Nicola Murgia
Lars Barregård
Gerd Sällsten
Ann-Charlotte Almstrand
P. Montuschi
G. Ciabattoni
Anna-Carin Olin
Published in Journal of Biological Regulators and Homeostatic Agents
Volume 30
Issue 1
Pages 263-270
ISSN 0393-974X
Publication year 2016
Published at Institute of Medicine, School of Public Health and Community Medicine
Pages 263-270
Language en
Keywords oxidative stress, wood smoke, exhaled breath condensate (EBC), 8-isoprostane, malondialdehyde, oxidative stress, airway inflammation, healthy, biomarker, Endocrinology & Metabolism, Immunology, Research & Experimental, Medicine, Physiology
Subject categories Health Sciences


Wood smoke, a well-known indoor and outdoor air pollutant, may cause adverse health effects through oxidative stress. In this study 8-isoprostane, a biomarker of oxidative stress, was measured in exhaled breath condensate (EBC) and urine before and after experimental exposure to wood smoke. The results were compared with measurements of other biomarkers of oxidative stress and inflammation. Thirteen subjects were exposed first to clean air and then, after 1 week, to wood smoke in an exposure chamber during 4-hour sessions. Exhaled breath condensate, exhaled nitric oxide, blood and urine were sampled before and at various intervals after exposure to wood smoke and clean air. Exhaled breath condensate was examined for 8-isoprostane and malondialdehyde (MDA), while exhaled air was examined for nitric oxide, serum for Clara cell protein (CC16) and urine for 8-isoprostane. 8-isoprostane in EBC did not increase after wood smoke exposure and its net change immediately after exposure was inversely correlated with net changes in MDA (r(s)= -0.57, p= 0.041) and serum CC16 (S-CC16) (r(p)= -0.64, p= 0.020) immediately after the exposure. No correlation was found between 8-isoprostane in urine and 8-isoprostane in EBC. In this study controlled wood smoke exposure in healthy subjects did not increase 8-isoprostane in EBC.

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