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Low Circulating Acute Brain-Derived Neurotrophic Factor Levels Are Associated With Poor Long-Term Functional Outcome After Ischemic Stroke.

Journal article
Authors Tara M Stanne
N David Åberg
Staffan Nilsson
Katarina Jood
Christian Blomstrand
Ulf Andreasson
Kaj Blennow
Henrik Zetterberg
Jörgen Isgaard
Johan Svensson
Christina Jern
Published in Stroke; a journal of cerebral circulation
Volume 47
Issue 7
Pages 1943-1945
ISSN 1524-4628
Publication year 2016
Published at Institute of Biomedicine, Department of Medical and Clinical Genetics
Department of Mathematical Sciences
Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
Pages 1943-1945
Language en
Links dx.doi.org/10.1161/STROKEAHA.115.01...
Keywords brain-derived neurotrophic factor, pathogenesis, risk factors, serum, stroke
Subject categories Neurosciences

Abstract

Brain-derived neurotrophic factor (BDNF) plays important roles in brain plasticity and repair, and it influences stroke outcomes in animal models. Circulating BDNF concentrations are lowered in patients with traumatic brain injury, and low BDNF predicts poor recovery after this injury. We sought to investigate whether circulating concentrations of BDNF are altered in the acute phase of ischemic stroke and whether they are associated with short- or long-term functional outcome.

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