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Genome-Wide Association Analysis of Young-Onset Stroke Identifies a Locus on Chromosome 10q25 Near HABP2.

Journal article
Authors Yu-Ching Cheng
Tara M Stanne
Anne-Katrin Giese
Weang Kee Ho
Matthew Traylor
Philippe Amouyel
Elizabeth G Holliday
Rainer Malik
Huichun Xu
Steven J Kittner
John W Cole
Jeffrey R O'Connell
John Danesh
Asif Rasheed
Wei Zhao
Stefan Engelter
Caspar Grond-Ginsbach
Yoichiro Kamatani
Mark Lathrop
Didier Leys
Vincent Thijs
Tiina M Metso
Turgut Tatlisumak
Alessandro Pezzini
Eugenio A Parati
Bo Norrving
Steve Bevan
Peter M Rothwell
Cathie Sudlow
Agnieszka Slowik
Arne Lindgren
Matthew R Walters
Jim Jannes
Jess Shen
David Crosslin
Kimberly Doheny
Cathy C Laurie
Sandip M Kanse
Joshua C Bis
Myriam Fornage
Thomas H Mosley
Jemma C Hopewell
Konstantin Strauch
Martina Müller-Nurasyid
Christian Gieger
Melanie Waldenberger
Annette Peters
Christine Meisinger
M Arfan Ikram
W T Longstreth
James F Meschia
Sudha Seshadri
Pankaj Sharma
Bradford Worrall
Christina Jern
Christopher Levi
Martin Dichgans
Giorgio B Boncoraglio
Hugh S Markus
Stephanie Debette
Arndt Rolfs
Danish Saleheen
Braxton D Mitchell
Published in Stroke; a journal of cerebral circulation
Volume 47
Issue 2
Pages 307-16
ISSN 1524-4628
Publication year 2016
Published at Institute of Biomedicine, Department of Pathology
Pages 307-16
Language en
Keywords Adult, African Continental Ancestry Group, genetics, Age of Onset, Aged, Asian Continental Ancestry Group, genetics, Brain Ischemia, complications, genetics, Chromosomes, Human, Pair 10, Computer Simulation, DNA, Intergenic, genetics, European Continental Ancestry Group, genetics, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Male, Middle Aged, Odds Ratio, Polymorphism, Single Nucleotide, Serine Endopeptidases, genetics, metabolism, Stroke, etiology, genetics
Subject categories Medical Genetics


Although a genetic contribution to ischemic stroke is well recognized, only a handful of stroke loci have been identified by large-scale genetic association studies to date. Hypothesizing that genetic effects might be stronger for early- versus late-onset stroke, we conducted a 2-stage meta-analysis of genome-wide association studies, focusing on stroke cases with an age of onset <60 years.

Page Manager: Webmaster|Last update: 9/11/2012

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