To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

Misfolding and aggregatio… - University of Gothenburg, Sweden Till startsida
To content Read more about how we use cookies on

Misfolding and aggregation of nascent proteins: a novel mode of toxic cadmium action in vivo.

Review article
Authors Markus J. Tamás
Bruno Fauvet
Philipp Christen
Pierre Goloubinoff
Published in Current genetics
Volume 64
Issue 1
Pages 177–181
ISSN 1432-0983
Publication year 2018
Published at Department of Chemistry and Molecular Biology
Pages 177–181
Language en
Subject categories Microbiology, Cell Biology, Molecular biology, Toxicology, Cell and molecular biology, Biochemistry, Biochemistry and Molecular Biology


Cadmium is a highly poisonous metal and a human carcinogen, but the molecular mechanisms underlying its cellular toxicity are not fully understood. Recent findings in yeast cells indicate that cadmium exerts its deleterious effects by inducing widespread misfolding and aggregation of nascent proteins. Here, we discuss this novel mode of toxic heavy metal action and propose a mechanism by which molecular chaperones may reduce the damaging effects of heavy metal ions on protein structures.

Page Manager: Webmaster|Last update: 9/11/2012

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?