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Three-dimensional molecularly imprinted electrochemical sensor based on Au NPs@Ti-based metal-organic frameworks for ultra-trace detection of bovine serum albumin

Journal article
Authors D. Duan
H. Yang
Y. Ding
Daixin Ye
L. Li
G. Ma
Published in Electrochimica Acta
Volume 261
Pages 160-166
ISSN 0013-4686
Publication year 2018
Published at Department of Chemistry and Molecular Biology
Pages 160-166
Language en
Keywords Au nanoparticles, Bovine serum albumin, L-cysteine, Metal-organic frameworks, Molecularly imprinted electrochemical sensor, Amino acids, Atomic force microscopy, Body fluids, Carbon, Crystalline materials, Electrochemical electrodes, Electrodes, Electron microscopy, Electropolymerization, Glass membrane electrodes, Gold, High resolution transmission electron microscopy, Hydrogen bonds, Mammals, Metal nanoparticles, Monomers, Organic polymers, Organometallics, Scanning electron microscopy, Surface plasmon resonance, Trace analysis, Trace elements, Transmission electron microscopy, Ultrasonic applications, Au nanoparticle, Bovine serum albumins, Metal organic framework, Molecularly imprinted, Electrochemical sensors
Subject categories Molecular biology


A novel three-dimensional molecularly imprinted electrochemical sensor (MIECS) was fabricated for ultra-trace detection of biomacromolecules bovine serum albumin (BSA), which was based on 3D porous electrocatalytic framework materials (AuNPs@NH2-MIL-125(Ti) composites) and graphene modified glassy carbon electrode. The AuNPs supported amino-functionalized Ti-benzenedicarboxylate porous metal-organic frameworks (Au/NH2-MIL-125(Ti)) was prepared by a simple and rapid ultrasonic method. The stable proteins molecularly imprinted polymers (MIPs) films were fabricated by electropolymerization using L-cysteine (L-Cys) as functional monomers and BSA as templates. The monomer L-Cys interact with AuNPs by Au–S bonds and interact with BSA by hydrogen bonding and electrostatic interaction, which was characterized with UV–vis spectra. The morphology of the MIP modified electrode was characterized by scanning electron microscopy, transmission electron microscopy and atomic force microscope. Under the optimal conditions, the 3D MIECS exhibited a wide linear range of 10−18 g mL−1 to 10−12 g mL−1 of BSA and an extremely low detection limit of 4.147 × 10−19 g mL−1. The 3D MIECS has been applied to the assay of BSA in liquid milk samples with satisfying results. © 2017

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