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Dispersed Uniform Nanoparticles from a Macroscopic Organosilica Powder

Journal article
Authors T. L. Church
Diana Bernin
A. E. Garcia-Bennett
N. Hedin
Published in Langmuir
Volume 34
Issue 6
Pages 2274-2281
ISSN 0743-7463
Publication year 2018
Published at Swedish NMR Centre at Göteborg University
Pages 2274-2281
Language en
Keywords folic-acid derivatives, silica nanoparticles, mesoporous silica, cancer-cells, supramolecular chirality, biomedical applications, spinodal decomposition, dissociation-constants, glutamic-acid, spheres
Subject categories Physical Chemistry


A colloidal dispersion of uniform organosilica nanoparticles could be produced via the disassembly of the non-surfactant-templated organosilica powder nanostructured folate material (NFM-1). This unusual reaction pathway was available because the folate and silica-containing moieties in NFM-1 are held together by noncovalent interactions. No precipitation was observed from the colloidal dispersion after a week, though particle growth occurred at a solvent-dependent rate that could be described by the Lifshitz-Slyozov-Wagner equation. An organosilica film that was prepared from the colloidal dispersion adsorbed folate-binding protein from solution but adsorbed ions from a phosphate -buffered saline solution to a larger degree. To our knowledge, this is the first instance of a colloidal dispersion of organosilica nanoparticles being derived from a macroscopic material rather than from molecular precursors.

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